Animal Virus Infections Studies

Detection of merbecoviruses in Danish bats using a novel broad-range RT-qPCR assay

The paper develops a broad-range RT-qPCR assay to detect merbecoviruses in Danish bats and identifies two new infections, including a novel lineage in Nathusius' pipistrelle.

Herpesvirus-based vaccine protects against bovine respiratory syncytial virus (BRSV) in calves with maternally-derived BRSV antibodies

This study shows a BoHV-4 vaccine vector protects calves with maternal antibodies against BRSV, even without high neutralizing antibody levels.

Coronavirus circulation and cross-species transmission in European bats: a new paradigm in betacoronaviruses

This study identifies coronavirus diversity and transmission dynamics in European bats, revealing new host associations and ecological factors facilitating cross-species transmission.

Porcine epidemic diarrhea virus Whole-Genome Diversity Reveals Divergence of Contemporary Populations in the United States

This study analyzes complete PEDV genomes to reveal temporal genetic differentiation and recombination in US PEDV populations, expanding the known geographic distribution of S1 clades.

Opposing roles of ACE2 and TMPRSS2 in IBV Beaudette infection

This study identifies ACE2 as a proviral host factor and TMPRSS2 as a restrictive factor for IBV BD infection in chicken cells.

A genome-wide CRISPR knockout screen identifies host dependency factors and potential viral-induced cell death regulators for porcine deltacoronavirus infection

The paper uses a CRISPR knockout screen to identify host factors and cell death regulators involved in porcine deltacoronavirus infection in swine cells.

Detection and characterisation of alpha- and betacoronaviruses in rodents and bats from Germany, France, Belgium and Ireland

This study detects and characterizes coronaviruses in rodents and bats from four European countries, identifying new viral lineages and highlighting potential zoonotic risks.

Discovery of two potential new species and two novel bat-coronavirus subgenera (Phyllacovirus and Phyllobecovirus) in the Neotropics

The paper identifies two new bat coronavirus subgenera and potential species from Neotropical bats using metatranscriptomic sequencing and phylogenetic analysis.

Disease investigation in a New Zealand high-health pig herd reveals a divergent porcine adenovirus

The paper identifies a novel divergent porcine adenovirus associated with a disease outbreak in a high-health pig herd, highlighting its potential role in reproductive and neonatal disease.

Metagenomic identification of novel Hepaciviridae in Australian birds reveals pegivirus recombination

The paper identifies two novel pegiviruses and two orthohepaciviruses in Australian birds, revealing recombination events and co-infections among avian hepaciviruses.

Systematic analysis of intracellular replication competence of mammalian, avian, and reptilian kolmioviruses.

The paper examines the replication competence of KoVs in cell lines from different vertebrate classes, finding host-specific replication patterns consistent with phylogenetic groupings.

A divergent betacoronavirus with a functional furin cleavage site in South American bats

The paper reports a new bat betacoronavirus from Brazil with a functional furin cleavage site in its spike protein, highlighting its phylogenetic distinctiveness and potential zoonotic risk.

Porcine epidemic diarrhea virus infection promotes Peyer's patch immune induction and epithelial defense via single-cell transcriptional reprogramming

This study uses scRNA-seq to analyze how PEDV infection alters transcriptional responses in intestinal epithelial and immune cells, identifying a conserved antiviral gene signature in enterocytes.

Inheritance of a Single Edited CD46 Allele Is Associated with Reduced Ex Vivo Susceptibility to Bovine Viral Diarrhea Virus

The paper shows that a single edited CD46 allele in cattle reduces susceptibility to BVDV in heterozygous state, despite functional wild-type allele expression.

Structural and biochemical analysis of the IBV nsp15 endoribonuclease reveals the necessity of peripheral site residues for activity

This study analyzes IBV nsp15 endoribonuclease structure and function, showing peripheral residues are critical for RNA cleavage and revealing species-specific RNA engagement mechanisms.

Conserved structural features of RNA export pores spanning the double membrane of arterivirus and coronavirus replication organelles

The paper models the arterivirus nsp2 and nsp3 proteins to identify conserved structural features of DMV pores, revealing their role in RNA export and viral replication.

Feline calicivirus encoding NanoLuc luciferase as a tool for assessing antibody neutralisation and antivirals

This paper develops a feline calicivirus reporter virus to assess antibody neutralisation and antivirals, identifying GS-441524 as a potential therapeutic.

The S1B-Targeting PEDV Neutralizing Antibody C62 Prematurely Activates S-trimer and Mimics Receptor Function

This study determines the structure of PEDV S1B bound by neutralizing and non-neutralizing antibodies, revealing how C62 targets a conserved epitope and influences viral entry and neutralization.

Shifts in Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus 2 in Vietnam Before and After African Swine Fever: Increased Diversity and Novel Sub-lineages

This study analyzes shifts in PRRSV-2 genetic diversity in Vietnam before and after ASF, finding increased diversity and novel sub-lineages.

Emerging parvovirus associated with an outbreak in Dutch pig farms also detected in pigs and wildlife in Denmark

The paper identifies a parvovirus linked to a Dutch pig outbreak also found in Danish pigs and foxes, suggesting farm-to-wildlife transmission.

Effect of CSFV on Differential Genes of Histone Lactylation at H3K18 in the PI3K-AKT Signaling Pathway

This study investigates how CSFV affects histone lactylation at H3K18 in the PI3K-AKT pathway, identifying 10 differential genes and showing increased THBS4 expression.

Identification of novel hepaciviruses in rock pigeon (Columba livia )

This study identifies three new hepaciviruses in birds, revealing phylogenetic incongruence and suggesting past cross-species transmission among avian hepaciviruses.

Isolation and characterisation of novel fruit bat alphaherpesvirus from Rousettus aegyptiacus bats in Coastal Kenya

This study isolates and characterizes two novel alphaherpesviruses from fruit bats in Kenya, providing partial genomic data and phylogenetic placement near primate viruses.

Comparison of Three Herd-Level Surveillance Methods for Porcine Reproductive and Respiratory Syndrome Virus

This study compares three herd-level surveillance methods for PRRSV, finding that DARO Systems detects the virus 1-2 days earlier than serum and oral fluids methods.

Structural Basis of Nidovirus Replication Organelle Evolution Revealed by the Arterivirus DMV Pore Complex

This study reveals the atomic structure of the arterivirus DMV pore complex, showing structural conservation with coronavirus counterparts despite differences in genome size and morphology.

Discovery of a cluster in the PRRSV Nsp1α leader protease reveals host-virus interplay in its downstream functions

The paper identifies a [4Fe-4S] cluster in PRRSV Nsp1α leader protease, showing its role in modulating protease activity and host-virus interactions.

A novel coronavirus associated with enteritis in broiler chickens, France, 2025

The paper identifies a novel gammacoronavirus causing enteritis in broiler chickens in France, distinct from known poultry coronaviruses.

Co-expression of IBDV VP2 and H9N2 HA by recombinant HVT induces high protection against both pathogens in chickens

Targeted metagenomic recovery of coronaviruses from wildlife samples

The paper uses metagenomic sequencing to recover and characterize full-length coronavirus genomes from bats and wild mustelids, expanding knowledge of coronavirus diversity and evolution in wildlife.

Double-membrane-spanning RNA export pores are a conserved feature in nidovirus replication organelles

This study identifies conserved double-membrane-spanning RNA export pores in arterivirus and coronavirus replication organelles, showing their role in RNA export and encapsidation.