Topic · Oncology · Medicine
Chemokine receptors and signaling
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
36 papers
- Developmental BiologybioRxivPreprint
Disruption of maternal ACKR3 has profound effects on embryos and offspring.
Ayumi Fukuoka, Gillian J. Wilson, Elise Pitmon…·Gerard J. Graham
This study shows that blocking maternal ACKR3 increases CXCL12 in embryos, leading to developmental issues and impaired immune responses in offspring.
DOI 10.1101/2023.06.15.545186 - BioinformaticsbioRxivPreprint
In silico analysis of single nucleotide polymorphisms (SNPs) in human C-C chemokine receptor type five (CCR5) gene
Asma Ali Hassan Ali, Muntaser Eltayeb Ibrahim
The paper analyzes SNPs in the CCR5 gene to assess their impact on protein structure and function, identifying deleterious variants associated with HIV resistance.
DOI 10.1101/2020.11.14.382739 - Molecular BiologybioRxivPreprint
Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential
Pandian Sokkar, Mirja Harms, Christina Martina Stürzel…·Elsa Sánchez‐García
The paper investigates how EPI-X4 binds to CXCR4 using simulations and experiments, leading to the design of more potent and safer CXCR4 antagonists.
1 citation - Molecular BiologybioRxivPreprint
Endothelial CXCL12 regulates neovascularization during tissue repair and tumor progression
Zeshaan N. Maan, Michael Sung-Min Hu, Robert Charles Rennert…·Geoffrey C. Gurtner
This study shows that endothelial CXCL12 is crucial for neovascularization in tissue repair and tumor progression by regulating endothelial-fibroblast interactions and recruiting neovascularization-supporting cells.
5 citations - Molecular BiologybioRxivPreprint
Role of Chemokine and TNF signaling pathway in oral squamous cell carcinoma: A RNA deep sequencing analysis of oral buccal mucosa squamous carcinoma model of Chinese hamster
Guoqiang Xu, Jianing Wei, Bing Huangfu…·Guohua Song
The paper uses RNA sequencing to analyze gene expression changes in a Chinese hamster oral buccal mucosa squamous carcinoma model, identifying differentially expressed genes in chemokine and TNF signaling pathways.
DOI 10.1101/778399