Erythropoietin and Anemia Treatment

The paper shows that deleting EPO in the forebrain of mice leads to increased expression of EPOR and EphB4, which may explain the lack of cognitive deficits in these mutants.

This study identifies an Epo-dependent CFU-E subtype, lateC, characterized by CD71hiCD105hi phenotype and its role in erythropoiesis.

This study shows that increasing erythroferrone in mice with CKD improves anemia by mobilizing iron and raising hemoglobin levels without worsening kidney function or inflammation.

The paper shows itaconate promotes differentiation of stress erythroid progenitors by increasing Nrf2 activity through anti-inflammatory signaling.

The paper designs bispecific agonists targeting EPO-R/CD131 to selectively activate signaling without engaging EPO-R/EPO-R, validated through structural modeling and functional assays.

The paper identifies a stress-specific erythroid progenitor population that links regenerative erythropoiesis to pathogenic erythrocytosis through Epo-IGF1R crosstalk.

This paper describes the design of a modified erythropoietin fusion protein that promotes red blood cell production and neuroprotection without causing thrombosis.

The paper designs a bifunctional AND-gate ligand to modulate cell-cell interactions by avoiding thrombosis and RBC adhesion.