Topic · Organic Chemistry · Chemistry

Synthetic Organic Chemistry Methods

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Synthetic Biology·ACS OmegaPeer-reviewed·May 12, 2025
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An emergent biosynthetic pathway to essential amino acids by metabolic metathesis
Julie Rivollier, Sandrine Gosling, Valérie Pezo…+1 more author·Philippe Marlière
The paper demonstrates the use of alkene metathesis to generate essential amino acids in E. coli by catalyzing the conversion of APE to vinylglycine, which is then used to synthesize isoleucine and methionine.
DOI 10.1021/acsomega.4c10463
E. coli·experimental assay
·𝕏 Post·Bluesky