Animal Disease Management and Epidemiology

This paper develops a farm distribution model to predict poultry farm locations and sizes in data-scarce regions, showing that spatial clustering increases disease transmission risk.

This study models the resource requirements for detecting an ASFV outbreak in the U.S., finding that sample collectors and lab capacity are critical to prevent delays.

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

The paper re-evaluates statistical analyses of the Randomised Badger Culling Trial, finding no effect of culling on cattle tuberculosis incidence and supporting the 2006 conclusion that badger culling is unlikely to help control cattle TB.

The paper models targeted vaccination strategies against PRRSV strains at the barn level, showing that strain-specific vaccines reduce infections, while multiple vaccines may be more effective when strains vary in vaccine response.

The paper compares the efficiency of population control methods for managing wild pigs during a foreign animal disease outbreak, finding aerial operations most cost-effective despite high initial investment.

This study investigates the role of the conserved S fragment in FMDV replication using SHAPE and genomic analyses, revealing its structural importance and interaction with 3Dpol.

The paper simulates a TAD control effort in wild pigs to identify operational challenges and propose solutions for rapid population reduction during a hypothetical outbreak.

This study reviews spatial and temporal risk factors for PPRV outbreaks in endemic regions, identifying key factors like livestock trade and spatial accessibility.

This study estimates FMD seroprevalence in cattle in Jimma Zone, Ethiopia, identifies risk factors, and detects FMDV serotype SAT 2, highlighting the need for vaccination and improved disease reporting.

This paper demonstrates how AI and software engineering methods can automate the creation of decision-support tools from mechanistic epidemiological models to aid farmers and veterinarians in disease control.

The paper models livestock herd movements in East Africa to predict how climate change impacts network dynamics and disease spread.

This study investigates the causes of livestock abortions in Tanzania using a surveillance platform, identifying pathogens and informing disease intervention priorities.

This study identifies B263R as an ASFV protein that inhibits autophagy by promoting proteasomal degradation of Beclin1, highlighting its role in viral replication and potential therapeutic targets.

EPINEST simulates epidemic dynamics in poultry production networks to study pathogen transmission and health hazards.

The paper analyzes swine movement networks in the U.S. to identify disease spread dynamics and evaluate control strategies based on shipment data and network metrics.

The paper introduces a method to distinguish viral RNA strands and investigates the role of cis-acting elements in FMDV replication.

The paper uses phylogenetic analysis to show impala act as an intermediate host for SAT1 and SAT2 FMD viruses in Africa, playing a more significant role than previously thought.

The paper develops and evaluates an RT-LAMP assay for rapid serotype O FMDV detection in Tanzania, showing it can amplify the virus within 26 minutes with high specificity.

This study identifies new variants of African swine fever virus (ASFV) with high-impact mutations, including a frameshift mutation in the PolX gene, and highlights the importance of genomic surveillance.

The paper models how targeting Rift Valley fever vaccination with imperfect livestock movement data can prevent outbreaks in northern Tanzania.

This study compares the potency of an FMD vaccine formulated with naloxone/alum mixture to alum-formulated vaccine, showing improved cytokine and IgG responses.

The paper investigates causes of livestock abortion in Tanzania using a cohort study and serosurveillance, identifying several infectious agents associated with abortions.

This study identifies BET/BRD4 inhibitors that suppress ASFV infection in pig macrophages by targeting viral replication and transcription.

This study shows that RNA pseudoknots in FMDV are not required for genome replication but are essential for producing infectious virus.

This paper presents a statistical model to predict herd-level infection probabilities from longitudinal data, applied to bovine viral diarrhoea virus control programs.

The paper investigates FMDV seroprevalence and molecular epidemiology in Eastern Rwanda, detecting SAT 2 lineage II and identifying other pathogens in African buffaloes.

This paper develops a continental-scale model for transboundary animal disease in Europe to support emergency planning and decision-making.

The paper enhances an epidemiological model to compare post-outbreak surveillance strategies for proving freedom from foot-and-mouth disease after emergency vaccination.

This paper models how gene editing and vaccination can reduce PRRS in pigs, finding that 10% gene-edited pigs in some herds with vaccination could eliminate the disease in 3-6 years.