Animal Disease Management and Epidemiology

This study identifies interactions between FMDV 2C protein and viral and host factors, revealing ER-derived replication complexes and potential targets for disrupting the FMDV lifecycle.

This paper develops a machine learning model to predict cross-neutralization potential between FMDV serotype O viruses using sequence data and identifies key genomic predictors.

This paper models PRRS transmission between pig herds in Denmark and evaluates the impact of control interventions, finding that undetected herds drive most transmission and eradication requires multiple strategies.

This study assesses the risk of African swine fever introduction through wild boar trade to France and Spain (2010-2017) and supports the 2018 EU trade ban.

The paper develops ANASFV, a pipeline for ASFV whole genome sequencing, assembly, and evaluation, addressing challenges like contamination, error rates, and recombination analysis.

This study tracks the rapid spread of African Swine Fever across Borneo using citizen science data and estimates the increasing speed of the virus's spread.

The paper evaluates how edge weight selection affects node ranking in a pig trade network, showing that strength centrality improves surveillance strategies by identifying critical holdings.

This study develops targeted whole genome sequencing protocols for ASFV and CSFV using MinION sequencing to enable rapid and complete genetic characterization of outbreak strains.

This study evaluates aggregate oral fluid sampling for early detection of African swine fever virus in pigs, showing it can detect ASFV as early as 3 days post-contact.

The paper explores how climate warming affects disease outbreak risk by considering both direct and indirect effects on host and pathogen dynamics in wild boars.

The paper evaluates vaccination strategies for Rift Valley fever in the Comoros archipelago, finding that optimal allocation improves effectiveness but creates inequity, while animal tagging enhances outcomes across all rates.

This study identifies BANF1 as a host factor essential for ASFV replication and reveals that A151R and MGF360-21R inhibit the IFN-I response, independent of BANF1.

The paper validates a bovine tuberculosis model against a field study of badger vaccination with selective culling, showing similar outcomes when social perturbation is excluded.

This study evaluates three sentinel surveillance strategies for detecting FMD outbreaks in Turkey, finding that all methods detect more outbreaks than random sampling, with spatial and network connectivity methods performing similarly.

This paper critiques Langton et al. 2022's analysis of badger culling's effect on cattle TB, identifying methodological flaws and demonstrating how their approach may lead to incorrect conclusions.

This study enhances the immunogenicity of viral capsid proteins by engineering them into membrane-bound or secreted forms, showing improved folding and T cell responses in animal models.

This study evaluates the antiviral activity of Termin-8 and Finio against the algal virus EhV, showing both products reduce viral load, with Finio achieving greater inactivation.

This study conducts a systematic review and meta-analysis to estimate the pooled seroprevalence of PPRV in sheep and goats in South Asia, finding 42.4% overall prevalence with variations by country and vaccination status.

This study examines immune dynamics in pigs infected with virulent ASFV, finding early disruption of the innate-adaptive immune axis and depletion of adaptive immune cells.

The paper selects and evaluates ASFV antigens for subunit mRNA vaccines, showing divergent immune responses and developing a computational method to design antigen cocktails.

The paper develops a framework integrating behavioural science and epidemiology to improve early detection of zoonotic swine influenza by simulating farmer responses and disease spread.

This study models ASFV transmission within swine barns, identifying between-pen contact as the primary route, with nose-to-nose contact contributing most, and aerosol transmission having minimal impact.

This study evaluates PEDV RNA contamination on swine transportation vehicles before and after cleaning, finding pigs-to-market trucks are most contaminated and quaternary ammonium/glutaraldehyde disinfectants are more effective.

This study assesses the distribution and control of African Swine Fever in the Dominican Republic using surveillance data from 2023-2024, finding a stable state with low attack rates and an R0 near 1.

This paper uses a mathematical model to identify intensified control strategies needed to eliminate African swine fever from U.S. swine populations within 12 months.

This study identifies the pseudoknot region and poly-(C) tract as essential RNA packaging signals for foot-and-mouth disease virus (FMDV) assembly, showing that their length and interactions influence packaging efficiency.

The paper simulates the spread of a PPR-like disease using mobility data to identify sentinel nodes and assess the impact of missing movement data on epidemic prediction.

The paper identifies sentinel nodes in Nigeria's livestock movement network to improve PPR surveillance, finding 45% of backbone nodes remain stable across configurations.

This paper develops a farm distribution model to predict poultry farm locations and sizes in data-scarce regions, showing that spatial clustering increases disease transmission risk.

This study models the resource requirements for detecting an ASFV outbreak in the U.S., finding that sample collectors and lab capacity are critical to prevent delays.