Optical Coherence Tomography Applications

This study compares physical and digital dispersion compensation in OCT, finding that digital methods can restore sensitivity but fail beyond a dispersion mismatch threshold.

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

The paper introduces an optoretinographic imaging platform to measure human retinal neuron responses to diverse stimuli and proposes a model to predict these responses.

This paper demonstrates a custom SD-OCT system for real-time guidance of cochlear implant electrode arrays in mice and cadaveric human temporal bones.

This paper demonstrates a method to measure retinal temperature rise in vivo using phase-sensitive OCT, showing differences in thermal deformation between healthy and degenerate retinas.

The paper develops an OCT+ERG system to image neurovascular coupling in the human retina and shows correlated neuronal and blood flow responses to visual stimuli.

This study introduces gold nanocages as scattering-dominant contrast agents for OCT, showing enhanced imaging contrast in tissue phantoms, ex vivo, and in vivo models.

This study develops gold nanocages with a surface plasmon resonance peak at 1060 nm as contrast agents for OCT imaging, showing enhanced imaging contrast in phantoms and mouse tissues.

This study uses OCT to track changes in stroke lesions after cell grafting, finding that lesion contraction and graft survival are influenced by lesion size and severity.

This paper develops a method to correct multiple scattering in qOCT to improve tissue attenuation coefficient accuracy, validated with phantoms and simulations.

This study uses PSOCT and ex vivo dMRI to image developing human brains, showing PSOCT's ability to quantify myelination and fiber orientation with micrometer resolution.

This paper demonstrates that tartrazine improves OCT imaging of the suprachoroidal space by reducing light scattering in ex vivo eye models.

This study introduces Bessel beam optical coherence microscopy to assess cerebrovascular network morphology and function in mice at high resolution and across multiple scales.

This study validates dynamic optical coherence tomography as a quantitative viability assessment tool for 3D cancer cell spheroids using trypan blue exclusion as a reference.

This study trains a conditional generative adversarial network to estimate tumor spheroid elasticity from phase difference images, showing improved robustness to noise compared to traditional methods.

This study uses PS-OCT to differentiate bone tissue types in prostate cancer metastases by analyzing collagen organization and quantifying structural features.

This paper introduces a multi-scale imaging technique combining PSOCT and 2PM to enable label-free, high-resolution analysis of human brain structure and pathology.

This paper introduces a method to measure 3D fiber orientation in the human brain using two illumination angles in PS-OCT, achieving high angular precision and detailed 3D maps.

This study compares optoretinography (ORG) and retinal densitometry for cone spectral classification, finding ORG offers higher sensitivity and reliability.

This paper introduces a velocity-based optoretinography method that measures subcellular retinal feature movement, demonstrating reproducibility and dose/retinal eccentricity dependence in healthy subjects.

This paper quantifies myelin content and neuron density in the human brain using OCT, finding a strong linear relationship between scattering coefficient and myelin content.

This study quantifies volumetric morphometry and optical properties of human cerebellar cortex at micrometer resolution using as-PSOCT, revealing layer-specific variations and cross-subject variability.

The paper introduces a method to quantify transient capillary stalls in OCT angiograms using maximum intensity projections and provides open-source code for reproducible research.

This paper introduces an algorithm to optimize generalized gamma distributed multiplicative noise in OCT images, improving speckle removal and contrast-to-noise ratio.

This paper introduces optoretinogram, a non-invasive method to image light-induced shape changes in human cone photoreceptors in vivo, revealing a biphasic response to light.