Timothy Mark O’Shea

This paper predicts recovery trajectories and injury severity after partial crush spinal cord injury in mice using behavioral data and statistical modeling.

This paper develops fructose dendrimer-based polyionic complexes for Glut5-specific intracellular drug delivery in murine brain, showing selectivity and toxicity profiles.

This study develops a tool to profile and modulate astrocyte borders at implanted biomaterials in mice, identifying metabolic regulation as a strategy to improve biocompatibility.

This study investigates slow speckle dynamics (SSD) in vivo to assess cellular metabolic activity using laser speckle contrast imaging, finding SSD correlates with metabolic processes and vascular dynamics.

This paper introduces DASIT, a protein-based circuit for antigen-specific cell selection, demonstrating its utility in genome engineering, CRISPR screening, and cell therapy manufacturing.

This paper presents a neurorecording toolkit to longitudinally assess transplanted human cortical organoids in vivo, showing increased neuronal activity and synchronicity over time.

This paper introduces a high-throughput scratch assay device for in vitro wound simulation, demonstrating its ability to create uniform, tunable scratches in neural progenitor cells.

This study uses OCT to track changes in stroke lesions after cell grafting, finding that lesion contraction and graft survival are influenced by lesion size and severity.

This paper develops HECMTP, an oxidation-responsive biomaterial that improves coating performance for medical devices by reducing fouling and delamination.

The paper identifies the cellular origins and functional changes of astrocytes forming protective borders around CNS injuries, showing their role in neuroprotection.

This study develops trehalose-based coacervates for targeted delivery of bioactive proteins to the CNS, showing high loading, controlled release, and compatibility with neural cells.

This study maps residual mechanical stresses in murine brains across age and after hemorrhagic stroke, finding increased stresses with age and reduced stresses post-stroke.

The paper shows that lesion environments, not pre-graft states, affect the survival and repair potential of neural progenitor and immature astrocyte grafts in stroke models.

This study identifies proliferation history and transcription factor levels as key drivers of direct conversion of fibroblasts to motor neurons using a synthetic biology approach.

This study shows that lesion environments direct transplanted neural progenitors to differentiate into neuroprotective astroglial cells in CNS injuries.

This study investigates CNS foreign body responses (FBRs) and shows they mimic wound responses, altering biomaterial functions based on interface properties.