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De novo Identification of DNA Modifications Enabled by Genome-Guided Nanopore Signal Processing
Marcus H. Stoiber, Joshua Quick, Rob S Egan…·James B. Brown
Base-by-base tests of raw nanopore current, native versus amplified DNA, detect 4mC, 5mC and 6mA without training data, recovering seven methylases' motifs (AUC 0.62–0.97).
276 citations