Topic · Genetics · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
36 papers
Madeline J. Caduc, Mohamed H. Elsafi Mabrouk, Martin Graßhoff…·Marcelo A. S. Toledo
This study identifies JAK2V617F zygosity-specific vascular changes in MPN and shows IFNα inhibits EndMT, offering a novel antifibrotic mechanism.
Stephen P. Chapman, Estelle Duprez, Élisabeth Rémy
The paper constructs a logical model of the myelofibrotic microenvironment to predict how TPO and TLR signaling disrupt stem cell crosstalk and drive disease progression.
Zhu Shen, Wenfei Du, Cecelia Perkins…·Anandi Krishnan
The paper identifies platelet transcriptome markers for predicting disease progression in MPNs and develops a machine learning model to predict advanced MF with high accuracy.
Melissa A. Castiglione, Yaping Jiang, Christopher Mazzeo…·Huichun Zhan
This study shows that JAK2V617F mutation in endothelial cells causes thrombosis, vasculopathy, and cardiomyopathy in a murine MPN model, suggesting targeting vasculature as a therapeutic strategy.
Sahar G. Elbager, Abier Abdelaziz Makkawi Abdelrahman, Hadeel A. Mohamed…·Magdi Bayoumi
The paper performs in silico analysis of missense variants in the MPL gene to identify those with potential functional impact on TPO-R structure and function in essential thrombocythemia.
Erik L. Bao, Satish Kumar Nandakumar, Xiaotian Liao…·Vijay G. Sankaran
This study identifies 14 genome-wide significant loci and a polygenic signature for myeloproliferative neoplasms, implicating hematopoietic stem cell function and self-renewal in disease risk.