HIV-related health complications and treatments

ALDH Activity in Monocytes is Associated with Subclinical Coronary Atherosclerosis in Treated People with HIV-1

The paper links ALDH activity in monocytes to subclinical coronary atherosclerosis in HIV-1 treated individuals, independent of traditional risk factors.

Plasma metabolomics reveals lipid-predominant metabolic disruptions in virologically suppressed people with HIV

The paper uses metabolomics to show that HIV-treated individuals have metabolic disruptions, including lipid changes and inflammation markers, despite viral suppression.

Metabolic and Redox Pathway Dysregulation in HIV-Associated Coronary Endothelial Dysfunction

This study identifies metabolic and redox pathway dysregulation in HIV-associated coronary endothelial dysfunction using proteomics and MRI.

The anti-retroviral therapy emtricitabine affects skeletal muscle DNA methylation and transcriptome patterns in a male HIV mouse model

This study examines how emtricitabine, an antiretroviral drug, alters DNA methylation and transcriptome patterns in skeletal muscle of HIV-infected mice, revealing potential mechanisms of ART-related muscle dysfunction.

Alterations in Circulating T-Cell Subsets with Gut-Homing/Residency Phenotypes Predict HIV-1 Status and Subclinical Atherosclerosis

The paper identifies specific T-cell subsets with gut-homing/residency markers that predict HIV status and subclinical atherosclerosis in ART-treated individuals.

Atorvastatin suppresses cardiac fibrosis and dysfunction induced by HIV and certain antiretroviral drugs in mice by blocking platelet TGFβ1

This study shows that atorvastatin reduces HIV and ART-induced cardiac fibrosis and dysfunction in mice by blocking platelet TGFβ1, independent of cholesterol changes.

Antiretroviral therapy in the peripartum period impairs post pregnancy cardiac reverse remodeling with early signs of heart failure with preserved ejection fraction

This study shows that antiretroviral therapy during pregnancy impairs postpartum cardiac reverse remodeling and may lead to early signs of heart failure with preserved ejection fraction.

Associations of inflammation-related proteome with demographic and clinical characteristics of people with HIV in South Africa

The paper identifies inflammation-related proteins associated with age, sex, and CD4+ cell count in HIV-positive individuals in South Africa, highlighting potential links to chronic diseases.

Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

The paper identifies three metabolic at-risk profiles in HIV-treated patients using multi-omics integration, highlighting dysregulated metabolism and microbiome interactions.

SiZer Map to investigate significant features of body-weight profile changes in HIV infected patients in the IeDEA Collaboration

The paper introduces PS-SiZer, a method for analyzing longitudinal biomarker data, and applies it to study weight gain durability in HIV patients on different ART regimens.