Evolution and Genetic Dynamics

This study investigates how mitotic gene conversion can purge deleterious mutations in asexual organisms and compares its effectiveness to self-fertilisation.

The paper develops a method to predict genetic barriers and coalescence times under polygenic divergent selection using a mainland-island model and validates it with simulations.

This study compares machine learning and statistical methods for detecting polygenic adaptation using simulated evolve-and-resequence data, finding that the OCSVM-FET approach performs best.

This study re-evaluates population stability in Drosophila by testing how generation length affects stability in populations selected for rapid development and early reproduction.

This study identifies natural selection on synonymous variation in MHC-I genes, showing purifying selection in most codon sites but spikes of variation in some sites linked to potential host-pathogen coevolution.

The paper introduces a geometric framework to analyze protein sequence space coverage and connects it to heuristic discovery times using a stochastic exploration model.

The paper uses experimental evolution in Drosophila to separate male and female gene pools, finding diverged genes show elevated intersexual genetic correlation and enrichment for male-biased splicing-related SNPs.

This study examines the effects of chromosomal inversion arrangements in Drosophila pseudoobscura on life history traits, finding support for the coadaptation hypothesis over pleiotropy.

The paper transplants stickleback populations across habitats to separate shared and site-specific adaptation, finding site-specific adaptation explains most fitness variation.

This study develops a theory to predict how rapidly adapting populations select for fitness tradeoffs in fluctuating environments, showing that mutations with larger tradeoffs can be favored despite lower geometric mean fitness.

This study investigates how directional and balancing selection influence mitochondrial haplotype evolution in Drosophila melanogaster under different thermal environments and genetic backgrounds.

The paper simulates seasonally fluctuating selection in Drosophila populations and shows it reduces genome-wide effective population size by ~50%.

The paper uses experimental evolution in yeast to study how recombination rates change under divergent selection, finding increased and decreased rates in selected lineages.

This paper introduces SLIDE, a method to estimate landscape ruggedness in directed evolution using population-level phenotypic data and mutation rate, improving selection strategies for protein design.

This paper uses a mathematical model to show that reduced inhibition and strong metabolic activity can stabilize ectosymbiosis between microbes, supporting the idea that syntrophy can lead to physical integration.

This study develops a modeling framework to investigate how fluctuating selection affects allele frequency oscillations by integrating quantitative and population genetics with simulations and spectral analysis.

The paper shows that environmental stress influences the phenotypic impact of de novo ORFs, with tradeoffs and stress-dependent growth effects observed in yeast.

The paper examines geographic variation in flower size in Arabidopsis thaliana, finding polygenic control and environmental influences on evolutionary direction.

The paper develops a value-of-information framework for microbial predator-prey interactions, showing how sensory information can disproportionately enhance survival benefits during encounters.

The paper shows that environmental changes alter proofreading enzyme rates, causing mutation supply fluctuations and evolutionary dynamics, with coding length and population size determining adaptation success.

The paper derives an analytical model showing how resident birth rates and invader specificity influence evolutionary rescue from antagonistic invaders.

The paper shows environmental stress more often causes loss of function than mutations, by reorganizing epigenomic topology rather than causing direct sequence damage.

This study estimates the fitness effects of new mutations in E. coli and finds they are small and heavily confounded with non-genetic variation.

The paper investigates how gene-level complexity influences genome-wide variation in the distribution of fitness effects across species.

This study shows copper-selected Drosophila melanogaster exhibit increased longevity and fecundity, with no difference in egg quality but higher developmental viability under copper stress.

The paper develops a metabolic model to compare hypotheses about the evolution of chemodiversity, finding support for the interaction diversity hypothesis over the screening hypothesis.

This study shows that self-fertilization changes the evolutionary pressure on a recombination modifier in C. elegans, reversing selection from positive to negative.

This study shows that increased collective β-lactam resistance in E. coli arises from activation of a dormant porin, NmpC, through an insertion sequence excision, enhancing drug permeability and filamentation.

The paper shows that temporal resource variation leads to growth equalization in bacteria through distinct metabolic strategies, reducing performance variance across conditions.

This study shows that gene conversion can create the appearance of soft sweeps even when selection acts on single-origin mutations, challenging previous assumptions about the prevalence of soft sweeps.