Thermal Regulation in Medicine

This study identifies SARAF as a repressor of the mild hypothermia response by regulating JUN and calcium dynamics, showing its role in cytoprotection against hypoxia.

This study shows that capsinoids induce mild hypothermia in aged mice after stroke, reducing brain injury and improving survival and functional outcomes.

This study shows that PGE2 alters temperature stimulus valence in zebrafish, making heating attractive and cooling aversive, challenging the idea that fever reduces perceived warmth.

This study identifies Foxp2+ neurons in the medial preoptic area as a controllable node for inducing therapeutic hypothermia and demonstrates their antitumor effects.

The paper shows that activating specific neurons induces hypothermia and metabolic changes that reduce brain injury after stroke, with benefits lost when temperature is normal.

This study examines the relationship between brain and body temperature in anesthetized animals using ultralocal thermometry, revealing non-linear dynamics and two distinct temperature response phases.

This study demonstrates that selective brain cooling using VINCI can reduce subacute injuries in a porcine model of severe ischemic stroke when guided by CT perfusion imaging.

The paper identifies molecular pathways causing fever through competitive inhibition of PGE2 and CORT at glucocorticoid receptors using mathematical modeling and case study validation.

This study shows that selective brain hypothermia reduces Fis1 expression, which mitigates focal cerebral ischemia-reperfusion injury in rats.