Neonatal and Maternal Infections

This study identifies a GBS T7SS-secreted toxin, BltA, that mediates interbacterial competition and vaginal colonization by inhibiting Enterococcus faecalis in vitro and in vivo.

This study shows that the hypervirulent GBS CC17 strain uses the HvgA adhesin to invade the choroid plexus, crossing the blood-CSF barrier through transcellular transcytosis.

The paper identifies three accessory gene clusters driving host adaptation in Group B Streptococcus across different hosts.

This paper introduces GBS-SBG, a serotyping tool for Group B Streptococcus using genome sequencing, achieving high concordance with PCR-based methods on both short-read and assembly data.

This study identifies genetic risk factors for late-onset neonatal sepsis, finding sex-specific associations and significant SNP-sex interactions.

The paper compares genomic differences between DNase-producing and non-producing Streptococcus agalactiae strains to identify genetic factors associated with DNase activity and virulence.

The paper performs RNA-sequencing to analyze global gene expression of S. agalactiae NEM316 during exponential growth, identifying translation-related genes and highlighting gaps in understanding DNase release mechanisms.

This study performs a pan-GWAS of Streptococcus agalactiae strains to identify lineage-specific genes linked to virulence and niche adaptation across different host environments.

The paper uses whole genome sequencing to analyze invasive GBS isolates in the Netherlands and identifies the expansion of a CC17 sub-lineage, CC17-1A, as correlated with increased disease incidence.

The paper evaluates the RALIS algorithm for early detection of late onset sepsis and necrotizing enterocolitis in premature infants using vital signs data.