Neonatal and Maternal Infections

This study identifies monocyte-specific miRNA expression changes in neonatal late-onset sepsis and links them to clinical markers like NLR.

This study shows that Candida albicans increases Group B Streptococcus burden and pathogenicity in the neonatal gut, with fluconazole reducing extraintestinal GBS spread.

This study identifies a 53-protein serum panel in newborns associated with three key biological processes in sepsis: pathogen sensing, immune activation, and endothelial injury.

This study surveys genomic surveillance practices in African labs, finding sufficient capacity but highlighting needs for improved infrastructure and standardization.

This paper analyzes the genomic characteristics of Streptococcus agalactiae ST1010 strains, showing they share virulence genes with CC17 and have a subclade with high-level gentamicin resistance.

The paper identifies GBS CC17's competitive advantage over non-CC17 GBS in neonatal gut colonization through metagenomic analysis and in vitro experiments.

This study shows that reducing glucose supply in preterm infants with infection reduces pulmonary damage and metabolic disturbances.

This paper develops a neonatal rat sepsis model and scoring system to monitor disease severity and time course in a clinically relevant polymicrobial sepsis context.

This study analyzes 37970 Streptococcus agalactiae genomes from BakRep to map population trends and identify metadata gaps in serotypes, lineage-specific genes, and AMR profiles.

This study shows that small intestine macrophage dynamics control GBS colonization and invasion in infant mice, with region-specific responses to the pathogen.

This study shows that meningeal γδ17 T cells promote bacterial entry into the brain during neonatal meningitis and cause long-term behavioral issues.

This study shows that inhibiting glycolysis or supplementing ketones can reduce inflammation and improve outcomes in neonatal sepsis by enhancing mitochondrial metabolism and disease tolerance.

The paper investigates antibiotic-resistant genes in bacterial pathogens from neonatal sepsis cases in Lagos, finding high resistance to common antibiotics and identifying Meropenem as a viable treatment.

The paper shows that boosting TCA cycle activity through nutritional strategies improves neonatal host defense against infection by enhancing disease tolerance and resistance.

The paper identifies three accessory gene clusters driving host adaptation in Group B Streptococcus across different hosts.

This study identifies genetic risk factors for late-onset neonatal sepsis, finding sex-specific associations and significant SNP-sex interactions.

The paper performs RNA-sequencing to analyze global gene expression of S. agalactiae NEM316 during exponential growth, identifying translation-related genes and highlighting gaps in understanding DNase release mechanisms.

The paper uses whole genome sequencing to analyze invasive GBS isolates in the Netherlands and identifies the expansion of a CC17 sub-lineage, CC17-1A, as correlated with increased disease incidence.