Boron Compounds in Chemistry

This study demonstrates lithium neutron capture therapy (LiNCT) in mice, showing improved tumor growth inhibition and survival compared to boron-based BNCT.

This paper introduces [B12H12]2- as a broad-spectrum nuclease inhibitor that preserves nucleic acids in biological fluids at room temperature for extended periods.

This paper demonstrates that bone marrow-derived macrophages loaded with boron carbide nanoparticles can effectively deliver boron-10 across the blood-brain barrier to glioma cells, showing potential for boron neutron capture therapy.

This study shows that restricting L-phenylalanine increases BPA uptake in tumor cells, enhancing BNCT efficacy and inducing ATF4 stress response through LAT1/4F2HC-mediated transport.

This paper develops carborane-NHS ester reagents for selective amine modification of biomolecules, demonstrating their use in conjugating antibodies with carboranes for boron neutron capture therapy.

This paper demonstrates that B-ASOLNA-CHOL, a boron cluster-conjugated antisense oligonucleotide, enhances cancer cell uptake and cytotoxicity when combined with radiotherapy, reducing tumor size in xenograft models.

This paper develops size-controlled boron-10 carbide nanoparticles for BNCT, showing improved tumour selectivity, reduced dosage, and enhanced antitumour immunity with minimal side effects.

The paper investigates the cytotoxic effects of transition metal metallacarboranes on triple-negative breast cancer cells and a vertebrate model, showing significant toxicity at nanomolar concentrations.