Topic · Orthopedics and Sports Medicine · Medicine

Bone and Joint Diseases

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Pharmacology & ToxicologybioRxivPreprintApr 30, 2026

Multidimensional Mechanistic Study of Panax Notoginseng Saponins in the Treatment of Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo Validation

This study identifies PNS active components, targets, and pathways for AIONFH using network pharmacology, molecular dynamics, and animal experiments, showing PNS inhibits osteocyte apoptosis through multi-component, multi-target mechanisms.

DOI 10.64898/2026.04.28.721283

ratstatistical model

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMar 10, 2026

ATG5 regulates autophagy-apoptosis-ER stress dysregulation in steroid-induced osteonecrosis of the femoral head (SONFH) pathogenesis

Kunkun Liu, Boyong Jiang, Wanlin Liu…·Zhenqun Zhao

This study investigates how ATG5 regulates autophagy, apoptosis, and ER stress in SONFH and shows that ATG5 silencing reduces pathology by blocking these pathways.

DOI 10.64898/2026.03.07.710256

ratbulk RNA-seq

𝕏 PostBluesky