Photoreceptor and optogenetics research

The paper shows that an improved ChETA variant (ChETATC) promotes aggression in mouse medial amygdala GABAergic neurons, suggesting previous results with ChETA were due to weaker photocurrents and stimulation conditions.

This paper introduces a neuropsin-based optogenetic tool, cOpn5, that enables precise control of Gq signaling with high temporal and spatial resolution.

This study shows that mutations in retinochrome opsin's binding pocket cause spectral tuning through epistatic interactions rather than additive effects.

The paper compares the behavioral effects of two optogenetic channelrhodopsin variants, finding that ChETA suppresses aggression while ChR2 increases it in mice.

The paper reevaluates the efficacy of nonhuman primate optogenetics for psychiatry, finding lower success rates when applying more relevant criteria to human neuropsychiatric disease.

This paper demonstrates a chemical-optogenetic approach that restores high-sensitivity motion vision in an IRD mouse model using a multi-branched photoswitch.

The paper engineers an improved fluorescent chloride sensor using directed evolution and coevolutionary analysis in E. coli.

The paper introduces Aion, a bistable anion-conducting channelrhodopsin with a long open state and precise light-switchable control, enabling extended neuronal silencing in Drosophila.

This paper engineers high-performance microbial opsins for precise spatial and temporal control of neuronal networks, enabling large-scale activation of defined neurons in vivo and in vitro.

The paper develops and tests a novel optogenetic silencer, PACK, in healthy and epileptic mice, finding it effectively inhibits neuronal activity but causes side effects.

This paper introduces a method to enhance two-photon optogenetic stimulation in live mouse brains by using fluorescent molecules to improve opsin activation efficiency.

The paper introduces an optogenetic tool that links neural activity to gene expression using a single AAV vector, improving temporal resolution and signal fidelity.

The paper investigates the relationship between pulse duration and optical power in optogenetic stimulation of dopamine neurons, finding a constant product of power and duration for reward seeking.

This study shows that optogenetic stimulation of the primate retina can activate the visual cortex for over 20 months, demonstrating long-term functionality and signal transmission.

The paper introduces improved genetically encoded voltage indicators for all-optical electrophysiology, revealing interneuron network dynamics in live mice.

This paper develops a wireless platform combining AI for high-throughput behavioral analysis with dual-channel optogenetics to study brain dynamics in freely behaving rats.

This study reveals the unidirectional chloride transport mechanism in NM-R3 using TR-SFX, showing conformational changes and halide binding site insights.

The paper develops a chronically implantable LED array for optogenetic perturbation in non-human primates and demonstrates its effectiveness in inducing visual deficits.

This study uses genetic code expansion and optical targeting in C. elegans to selectively activate gene expression in specific neurons and analyze their role in behavior.

BiPOLES is an optogenetic tool that allows bidirectional control of neuronal activity using two different light colors, enabling both excitation and inhibition of the same neurons in a single experiment.

This paper demonstrates the use of X-ray-induced scintillation to remotely control neural function in mice, achieving bidirectional modulation of behavior through optogenetic activation and inhibition.

This study demonstrates the use of DREADD to manipulate tissue-specific bioelectrical activities in zebrafish, showing voltage changes and morphological effects in melanophores, epidermis, and neurons.

This study uses optogenetics in macaques to investigate cortical activation patterns related to visual phosphenes, revealing laminar and large-scale network responses.

This paper introduces parapinopsin (PPO), a photoswitchable GPCR-based opsin that enables rapid and reversible presynaptic inhibition, and demonstrates its utility in vivo.

The paper develops a novel genetically encoded voltage indicator, NovArch, enabling high-resolution voltage imaging in brain tissue with improved sensitivity, background rejection, and time resolution.

This paper demonstrates optogenetic delivery of trophic signals using light-activated receptors to suppress disease phenotypes in Parkinson's disease models.

The paper measures light penetration through rodent brain tissue using nucleated patches and direct visualization, finding a lower extinction coefficient than previous estimates.

The paper introduces an affordable optogenetic device called OptoArm for manipulating C. elegans worms, showing that cholinergic neurons decline with age while GABAergic neurons and muscle cells remain resilient.

This paper demonstrates that Lamplight, a bistable opsin, can be used for switchable and scalable optogenetic inhibition of neurons in mice.

The paper develops LiCre, a fast-responding light-inducible Cre recombinase, and demonstrates its efficiency in yeast and human cells.