Tissue Engineering and Regenerative Medicine

Modular biofabrication of a vascularized skeletal muscle model through endothelialized microvascular seeds

This paper develops a modular biofabrication strategy to create a vascularized skeletal muscle model by separately maturing muscle and vascular compartments and then assembling them.

An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

Translating Sex- and Disease-Informed Design Criteria from Human Lung into Engineered Biomaterials

This study develops sex- and disease-informed biomaterial design criteria from human lung tissue to create engineered hybrid-hydrogels that recapitulate mechanical and biochemical features of IPF.

Time-Evolving Immunomodulatory Activity in Green-Fixed Devitalized Cellular Materials

This study shows that ethanol-based fixation preserves immunomodulatory activity in MSC-derived microtissues, with functional potency increasing over 8 weeks of storage.

Evaluation of Densified Collagen Tubes as an Interposition Graft in Abdominal Aorta

This study evaluates densified collagen tubes as interposition grafts in rat abdominal aorta, showing patent grafts for 17 weeks with neointima formation and re-endothelialization but late thrombosis.

Venous Angiogenesis and Dermal Fibroblast Augmentation of Decellularized Dermis: Towards Transplantable Dermal Substitutes

This study shows that a flexible decellularized dermis can be vascularized around a single vein, with fibroblasts enhancing vascularization, and demonstrates improved vascular outcomes compared to subcutaneous implantation.

Stimulatrix: An open-source automated platform for high-throughput functional characterization of engineered contractile tissues

Stimulatrix automates the functional analysis of engineered muscle tissues using video acquisition, electrical stimulation, and deep learning to quantify contractile properties over time.

Acoustically patterned hepatic lobule-like units for vascularized artificial liver

This paper develops an ultrasonic method to create vascularized hepatic units with improved function and integration in mice.

A human engineered mini-heart platform for mimicking ventricular pump function

This paper develops a human mini-heart model that mimics ventricular pump function through sacrificial molding and bioreactor technology, enabling non-invasive hemodynamic measurements and drug response testing.

Multilayer and Biomimetic Polycaprolactone/Uterine ECM Scaffold for Uterine Tissue Engineering and Anti-Adhesion Barrier Applications via 3D-Printing Near-Field Melt Electrowriting

This paper develops a 3D-printed multilayer scaffold combining polycaprolactone and decellularized uterine ECM hydrogel to create a biomimetic material for uterine tissue engineering and anti-adhesion barriers, showing improved mechanical and biological properties.

Evaluation of the Translational Readiness of Pluripotent Stem Cell-Derived Vascular Cell Therapy for Limb Ischemia: A Systematic Review and Meta-analysis

Resolving differential vascular graft remodeling using longitudinal multiphoton tracking in a 3D culture platform

This study develops a 3D culture platform to track vascular graft remodeling using multiphoton imaging, showing differential responses to TGF-β isoforms and agreement with long-term explant data.

Engineering in vitro models of skeletal muscle with neuromuscular junctions using hierarchical micro-nano biomaterials: Cooperative effect of adhesion ligand nanoclustering and surface anisotropy

This study develops hierarchical micro-nano biomaterials to enhance in vitro skeletal muscle maturation and neuromuscular junction formation by optimizing surface topography and ligand clustering.

A Biophysical Platform for Electromechanical Stimulation of Engineered Cardiac Tissues

This paper develops a biophysical platform to deliver electromechanical stimulation to engineered cardiac tissues and shows that synchronized stimulation increases contractile force.

Self-feeding living materials enabled by cell responsive glycogen nanoparticles as metabolic batteries

This paper introduces glycogen-based nutritional nanoparticles as metabolic batteries to support long-term survival of human mesenchymal stromal cells under extreme metabolic stress and enables scalable living materials.

Extracellular matrix composition is associated with tissue-specific decellularization susceptibility and mechanical remodeling across human urogenital tissues

This study shows that ECM composition determines tissue-specific decellularization outcomes and mechanical properties, advocating for ECM-focused quality assessment in regenerative medicine.

Advancing Cardiac Tissue Engineering: Melt Electrowriting Conductive Polymer-Hydrogel Scaffolds

This paper develops conductive polymer-hydrogel scaffolds for cardiac tissue engineering using melt electrowriting, showing that gold coating supports better contractile activity than other conductivity methods.

Placental derived Extracellular Matrix Supports multi-lineage cell attachment and nuclear remodeling revealed by quantitative imaging

This study shows that placental-derived extracellular matrix supports cell attachment and induces lineage-specific nuclear remodeling, detected through quantitative imaging and deep learning.

Comparative proteomic analysis of the composition of decellularized extracellular matrix (dECM) and dECM-based inks as compared to the native tissue

The paper compares the proteomic composition of decellularized extracellular matrix (dECM) and dECM-based inks to native tissues, finding increased collagen proportions in inks and a core matrisome shared across all dECMs.

Coalescing nephron and ureteric bud progenitors potentiates nephrogenesis in recellularized kidney scaffolds

This paper demonstrates the generation of advanced bioengineered kidney tissues using decellularized scaffolds and human pluripotent stem cell-derived progenitors, showing functional integration in vivo.

Encoded cell-material interactions to reroute cytokine signaling for regenerative medicine

The paper introduces nMATRIX, a material-cell platform that converts inflammatory cytokine signals into anti-inflammatory cues to reprogram macrophage phenotypes.

The overlooked role of muscle regeneration failure in post-implantation complications: a thorough investigation into mechanisms of recurrent urethral stricture

This study investigates muscle regeneration failure in urethral reconstruction, finding that incomplete muscle regeneration leads to profibrotic responses and recurrent stricture.

Aligned basement membrane-modified collagen scaffolds for skeletal muscle tissue engineering

This study develops collagen-glycosaminoglycan scaffolds with aligned pores and basement membrane proteins to enhance skeletal muscle tissue engineering.

Particle-Only gECM Wafers Enable Cohesive, ECM-Rich Scaffolds Without Secondary Polymers

This study shows particle-only gECM wafers match hydrogel wafers in mechanical and biological performance without needing secondary polymers.

Finite afterload during asymmetrically cycled preload promotes fetal ventricular growth, maturation, and contractile function while suppressing fibrotic remodeling

The paper investigates how asymmetrically cycled preload with low afterload promotes fetal ventricular growth, maturation, and contractile function while reducing fibrosis in chick myocardial tissue.

Aligned multicompartment collagen scaffolds support stratified myoblast and fibroblast behavior for musculotendinous tissue engineering

This paper develops a multicompartment collagen scaffold with aligned pores and conductive regions to mimic the muscle-tendon junction, supporting stratified cell behavior and maintaining mechanical properties.

Recreating the Native Airway Microenvironment Using Tissue-Specific Extracellular Matrix Bioinks for Proximal Airway Engineering

This paper develops a bioink using decellularized extracellular matrix to create functional airway structures, showing viability and mechanical properties similar to native airways.

Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and function

This study develops bioengineered liver tissues using multiple cell types and synthetic hydrogels, showing improved structure, function, and maturation.

Miniaturized subcutaneous cellular implants for sustained therapeutic protein delivery in resource-limited settings

A miniaturized cell encapsulation platform enables sustained therapeutic protein delivery in resource-limited settings through minimally invasive implantation and retrieval.

Partial decellularization of kidneys during prolonged acellular perfusion

This study tests partial decellularization of kidneys using SDS during perfusion to remove donor endothelium, finding it removes endothelial cells but impairs renal function.