Francesco Paneni

This study shows that increasing hydrogen sulfide in aged mice reduces vascular senescence and reverses vascular remodeling.

Stimulatrix automates the functional analysis of engineered muscle tissues using video acquisition, electrical stimulation, and deep learning to quantify contractile properties over time.

This study identifies phenylacetate (PAA), a gut microbiota metabolite, as a driver of vascular niche senescence and atherosclerosis in mice through IL-6-Notch1 signaling.

This study shows that gut microbiota-dependent phenylacetic acid (PAA) increases endothelial cell senescence and impairs angiogenesis in aging, with acetate able to reverse these effects.

This study shows that SETD2 promotes lipotoxic injury in cHFpEF by regulating SREBP1 and lipid metabolism, and its inhibition improves cardiac function.

This study identifies AQP1 as a regulator of endothelial cell senescence and angiogenesis, showing its dual role in proliferating and senescent cells through modulation of the HDAC4-Mef2A pathway.