Tissue Engineering and Regenerative Medicine

The paper introduces gECM hydrogel wafers as shelf-stable 2.5D substrates for microphysiological modeling, showing they support cell viability and function comparable to 3D hydrogels.

This study identifies a fibrillin-1 derived peptide that enhances cardiomyocyte proliferation and reduces fibroblast activation, suggesting potential as a cardiac regeneration therapy.

This paper develops a tunable vascular dECM platform to study stiffness-driven vascular remodeling and identifies YAP and survivin as regulators of VSMC mechanotransduction.

This study shows electrical stimulation promotes the formation of functional, perfusable vasculature in engineered tissues by inducing endothelial cell hyperpolarization via KV channels.

This study shows fibrous granular scaffolds with directional persistence guide myotube organization better than isotropic scaffolds.

This study develops a multi-point drug delivery system to improve myocardial drug distribution in swine, overcoming transport barriers caused by dense myocardial fibers.

This paper develops microporous immune-isolating capsules that restore dynamic hormone signaling in a mouse model of premature ovarian insufficiency by enabling size-selective diffusion of hormones.

This paper develops a cell-scaffold platform using bovine ESC-derived mesenchymal stem cells and soy-based scaffolds to generate structured cultivated meat with high-density biomass accumulation.

This paper develops a method to grow engineered liver tissue in vivo by using synthetic biology to trigger on-demand expansion after implantation.

This paper develops a micro-patterned vascular graft using hiPSC-derived cells that enhances endothelialization through engineered shear stress distribution.

This paper develops a 3D-printed bioadhesive patch with electrical and mechanical properties to modulate cardiac tissue repair and immune responses.

This study examines how porous device design influences fibroblast activation into myofibroblasts, showing that polymer degradation and nanoparticle surface features significantly impact fibrotic responses.

This study investigates how diseased extracellular matrix (ECM) from MASH-derived organs affects cell physiology and disease progression in vitro and in vivo.

This paper develops a paracrine factor local gradient system to create vascularized hepatocyte tissues that proliferate under perfusion.

This study develops a decellularized adipose tissue-derived hydrogel (atdECM) that supports pancreatic organoid growth with improved transcriptional profiles compared to Matrigel.

This study develops 3D ovarian scaffolds using decellularized extracellular matrix and mechanically tuned hydrogels to improve in vitro ovarian models.

The paper develops INSITE, an injectable platform for hepatocyte transplantation that enables precise delivery and long-term function through image-guided assembly into vascularizable scaffolds.

This study uses photo-clickable decellularized matrix hydrogels to generate pancreatic ductal organoids from iPSCs, showing that stiffer hydrogels promote ductal differentiation over mesenchymal.

This paper introduces dECM-AoAO organoids that better recapitulate native airway epithelial composition and function compared to ECM-free models.

This study evaluates bacterial translocation in 3D printed vascular graft materials using confocal microscopy to assess penetration depth and breakthrough of E. coli and S. aureus.

This study shows that lyophilized cell-secreted matrix supports chondrocyte expansion, maintains cartilage markers, and reverses dedifferentiation without growth factors.

This paper develops a decellularized porcine small intestine scaffold for burn wound treatment, showing good mechanical properties, fluid absorption, and cytocompatibility.

This study develops vascularized cardiac microtissues from human iPSCs and shows they improve cardiac function and vascular integration in a rat MI model.

This study shows heparin-modified collagen-GAG scaffolds enhance myoblast metabolic activity and myogenic differentiation compared to other GAG scaffolds.

This study develops cell-assembled decellularized adipose tissue scaffolds for co-delivering ASCs and ECFCs to enhance soft tissue regeneration, showing improved ECFC retention and vascular regeneration.

The paper develops and validates new methods for ECM decellularization and collagen purification that preserve structural and biochemical integrity, applicable to various cell types for tissue engineering and drug discovery.

The paper describes a hybrid cell culture method combining 2D and 3D cultured cells from human buccal tissue to repair urethral stricture, showing increased epithelial markers in 3D cultures and higher IGF-1 secretion in 2D cultures.

This study uses snRNAseq to identify cell-specific pro-repair responses induced by an infusible ECM biomaterial after myocardial infarction.

This paper develops a miniaturized flow chamber to assess calcification in biohybrid implants under physiological flow conditions, showing similar calcification in bovine pericardium and no calcification in polycarbonate urethane.

This study shows that piezoelectric nanofiber scaffolds promote faster spheroid formation and support intestinal organoid development without adverse effects.