Kirk Charles Hansen

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

This study shows that human milk-derived mammary epithelial cells form organoids that respond differently to various extracellular matrix environments, revealing ECM's role in shaping morphogenesis and lactation states.

The paper shows that collagen abundance alone does not define fibrosis in DMD, as distinct matrix states with different biological activities and mechanosignaling exist.

This study develops human-derived granular extracellular matrix hydrogels for osteochondral repair, showing distinct biochemical and mechanical properties between cartilage and bone gECM.

This study develops and characterizes granular ECM hydrogels for five tissues, showing they retain shape, stability, and support tissue-specific cellular activity.

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

This study shows that long-distance trail running causes inflammation, lipid, and purine oxidation in red blood cells, indicating systemic inflammation and metabolic changes as key factors in RBC damage.

This study shows that deleting Yap/Taz in mouse dermal fibroblasts impairs collagen production and deposition, affecting postnatal skin development.

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

This study shows that TGFβ from cardiomyocytes programs fibroblast development and ECM environment to support cardiomyocyte maturation in the developing heart.

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

This study compares ECM proteomic changes during ear punch regeneration in Acomys cahirinus and Mus musculus, identifying differences in ECM proteins, crosslinking enzymes, and CD206 expression.

This study identifies proteomic changes in non-fibrotic lung tissue associated with the MUC5B promoter variant, linking them to fibrosis progression.

This paper develops a 3D biomimetic scaffold model to support in vitro lactation by human milk-derived mammary epithelial cells, enabling secretion of beta-casein and milk-fat-globules.

This study uses untargeted peptidomics and thrombolysis assays to analyze the clot-degrading effects of six snake venoms, revealing specific targets and mechanisms of thrombolysis.

The paper identifies genetic factors influencing red blood cell proteome and oxidative stress in mice, highlighting hemoglobin cysteine redox status as critical for glutathione regulation.

This study develops a light-based bioprinting method using decellularized extracellular matrix to create anisotropic cartilage scaffolds that promote tissue maturation and mimic native structure.

This study investigates how metabolic changes in endocrine-resistant ER+ breast cancer cells affect ER DNA-binding patterns and shows that DMF can restore sensitivity to endocrine therapies by targeting metabolic vulnerabilities.

The paper identifies a novel inter-subunit interaction in the SIR complex that facilitates the switch from histone deacetylation to chromatin compaction, essential for gene repression.

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

This study investigates how aging-related inflammation contributes to lung cancer development by analyzing gene expression data and using mouse models to assess the role of inflammation in oncogenesis.

The paper identifies PP1 phosphatase activity in the PPWZ complex as essential for antisense transcription termination by dephosphorylating RNA pol II CTD Ser5.

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

Trans-omics analysis of longitudinal plasma samples from severely injured patients identifies endotypes and trajectories that predict clinical outcomes.

This study uses multi-omic data to identify age-related changes in lung cell composition and molecular programs associated with aging and senescence.

This paper creates a mass spectrometry-based atlas of ECM proteins across 25 mouse organs, revealing shared and tissue-specific ECM protein profiles.

This study uses multi-omics analysis to show that sarcospan overexpression in mdx mice compensates for dystrophin deficiency by altering cytoskeleton-matrix interactions and mechanotransduction pathways.