IL-33, ST2, and ILC Pathways

This study shows pregnancy reduces Il33+ hybrid progenitor cells in aged mammary glands, improving lineage integrity and potentially lowering breast cancer risk.

This study shows that perinatal RORγt+ ILC3s are essential for dural lymphatic vessel development in mice.

The paper shows tuft cells release acetylcholine to directly target helminth parasites in the gut, enhancing type 2 immunity.

The paper describes methods to study eosinophil-cancer cell interactions using IL-33 stimulation and flow cytometry/video tracking.

This study shows that RAG suppresses group 2 innate lymphoid cells (ILC2s), affecting their cytokine production and contributing to inflammation in atopic dermatitis.

The paper shows that loss of Paneth cells in mice alters gut ILC subsets and increases weight gain on a high-fat diet.

This study shows that ACC1 regulates adipose ILC2 differentiation and function in obesity, linking lipid metabolism to metabolic health.

The paper investigates how IL-33-induced gene expression in Th2 cells depends on IL-1RL1 haplotype and asthma status, finding stronger effects in risk haplotype carriers and a correlation with pauci-granulocytic asthma.

The paper maps promoter interactions in human ILC3s using PCHi-C and links GWAS risk variants to target genes, identifying new autoimmune disease risk genes.

This study shows IL11 promotes inflammation in fibroblasts by upregulating IL33 and other proinflammatory genes, with STAT3 signaling being critical for this effect.

The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.