Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology

Protein Degradation and Inhibitors

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Biochemistry·Nature CommunicationsPeer-reviewed·Aug 20, 2025
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Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics
Martin Steger, Gisele Nishiguchi, Qiong Wu…+17 more authors·Zoran Ranković
Proteomics and ubiquitinomics screening of 100 CRBN ligands in two cell lines validated 50 novel neosubstrates and yielded selective phenyl glutarimide degraders of KDM4B, G3BP2 and VCL.
40 citationstop 1%
human·proteomics
·𝕏 Post·Bluesky