Psychedelics and Drug Studies

The paper shows psilocybin promotes lasting social behavior in autism models, which is reversed by DNA methyltransferase inhibition.

The paper investigates phenethylaminylation, a potential covalent modification of glial proteins by psychedelics, using a propargylated mescaline analog and click-chemistry in astrocyte cultures.

The paper classifies psychedelics and psychoactive drugs using brain-wide imaging of c-Fos expression and machine learning, achieving above-chance accuracy in drug identification.

This study examines how DMT affects brain oscillation criticality and links these changes to ego-dissolution experiences.

This study examines the neural and subjective effects of medium- and high-dose DMT using EEG and experience tracking, finding that higher doses induce more intense experiences but less strong neural complexity correlations.

This study shows that immersive simulated visual hallucinations reduce task-switching costs and modulate high-level cognitive processes in humans.

This study shows that DOI, a serotonergic psychedelic, can reverse general anesthesia and restore brain dynamics in rats, as evidenced by behavioral arousal and recovery of functional connectivity.

This study identifies persistent, cell type-specific alternative splicing changes in mouse prefrontal cortex neurons after a single psychedelic dose.

This study shows psilocybin induces cell-type specific transcriptional changes in mouse medial prefrontal cortex, with sustained neuroplastic effects mediated by 5-HT2C signaling in L5/6 NP neurons.

This study uses single-nucleus RNA sequencing to show psilocybin and ketamine induce cell type-specific and time-dependent gene expression changes in mouse medial frontal cortex neurons.

This study identifies brain substates and autonomic correlates during DMT administration, linking hippocampal and medial parietal deactivations to altered consciousness and sympathetic output.

This study examines how psilocybin affects visual salience processing by analyzing eye-tracking and EEG data during natural scene perception.

This study shows that DOI, a serotonergic psychedelic, increases neural response variability and impairs deviance detection in the auditory cortex of mice by reducing sensitivity to unexpected sounds.

This study examines how classical psychedelics alter brain hierarchy and complexity, finding they reduce hierarchy while increasing neural complexity.

This paper shows that a single dose of 25CN-NBOH improves cognitive flexibility in mice weeks later, using a complex reversal learning task.

This study examines dose- and sex-dependent transcriptional changes in mice brains after psilocybin administration, finding prolonged effects of low doses and sex-specific molecular responses.

This study investigates the rewarding effects and synaptic plasticity induced by LSD and 25CN-NBOH in mice, finding no reliable conditioned place preference but evidence of synaptic changes in VTA dopamine neurons.

This study shows LSD reduces directed information hierarchy in the brain by balancing signal sending and receiving, as measured by MEG data.

This study examines how psilocybin affects neural network dynamics in rat prefrontal cortex over time, finding increased beta and low-gamma power in infralimbic cortex days after administration.

This study investigates how 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT1A receptor antagonists affect mescaline-induced behavioral changes in rats, finding that 5-HT2A receptors primarily mediate these effects.

This paper investigates the long-term effects of psilocybin on fronto-striatal-thalamic circuit dynamics and connectivity using longitudinal fMRI data and computational modeling.

This study identifies specific pyramidal cell types and 5-HT2A receptors in the medial frontal cortex as essential for psilocybin's long-term therapeutic effects.

This study shows that acute psilocybin reduces compulsive behavior in SAPAP3 knockout mice, with effects lasting up to 8 days post-injection.

This study compares the neural effects of 2C-B and psilocybin using fMRI, finding distinct patterns in functional connectivity and brain complexity.

This meta-analysis examines how classic psychedelics affect empathy, finding they enhance emotional empathy but not cognitive empathy.

The paper develops a non-radioactive method to measure 5-HT2A receptor activation in the mouse brain via IP1 detection and correlates it with behavioral and pharmacological responses.

This study shows that a single dose of psilocybin or psychedelic mushroom extract reduces excessive self-grooming in SAPAP3 KO mice, with effects lasting up to 7 weeks.

This study examines how 5-MeO-DMT alters human brain dynamics by reorganizing low-frequency neural activity patterns observed through EEG.