Psychedelics and Drug Studies

This study uses computational models to show that psilocybin increases reward acquisition in rats by enhancing task engagement through altered forgetting rates and reduced loss aversion.

This paper proposes the oneirogen hypothesis, suggesting classical psychedelics induce hallucinations by shifting neural activity toward dream-like states, and validates this through simulations using a wake-sleep neural network model.

This study shows psilocybin prevents habituation of sound-evoked responses in mouse primary auditory cortex, maintaining responsiveness and thresholds after repeated stimulation.

This study investigates how midazolam affects memory and subjective experience of psilocybin, suggesting memory plays a role in its therapeutic effects.

This study uses proteomics to show LSD alters proteins involved in proteostasis, energy metabolism, and neuroplasticity in human brain organoids.

This study investigates how psilocybin affects fear extinction in mice, finding that dose, context, and serotonin receptors are critical factors.

The paper investigates how breathwork-induced psychedelic experiences affect neural dynamics using EEG and subjective reporting.

This study shows that psychedelics reduce predictive processing by weakening top-down cortical feedback circuits, an effect observed in both humans and mice.

This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.

This study shows that DMT alters connectome harmonics, increasing their repertoire entropy and correlating with subjective experience intensity over time.

This study shows that activating prefrontal cortex 5-HT2AR neurons alone does not induce head-twitch responses in mice, but their inhibition prevents DOI-induced responses, with sex-dependent effects.

This study shows that 5-MeO-DMT induces sleep-like LFP patterns in awake rats' hippocampus and prefrontal cortex, independent of locomotion and theta power changes.

This paper shows that LPH-5, a selective 5-HT2A receptor agonist, produces antidepressant-like effects in rodent models, suggesting its potential as a new psychedelic-derived antidepressant.

This paper develops a computational model of cortical dynamics to explain the therapeutic effects of serotonergic psychedelics and proposes a hypothesis for their clinical success.

This study links psilocybin-induced brain dynamics with phenomenological changes, showing hyperconnectivity correlates with oceanic boundlessness.

This paper describes the cultivation, chemical profile, and genome of Psilocybe zapotecorum, revealing its psilocybin content and gene cluster structure.

This study shows that the psychedelic DOI increases dopamine signaling to reward cues but not distal cues, supporting error-driven learning mechanisms.

This study challenges the idea that psychedelics induce neuroplasticity by showing they do not modulate TrkB or BDNF-TrkB signaling or cause dendritic growth in neuronal cultures.

This study examines how psilocybin affects brain network organization in rats, finding dose-dependent changes in connectivity and phase-amplitude coupling.

This paper models the transient brain state changes induced by DMT using a time-dependent whole-brain model and fMRI data, showing heightened reactivity in specific brain regions correlated with serotonin receptor density.

The paper explores how psychedelics affect neural dynamics by flattening the neural landscape, increasing complexity, and promoting adaptability through changes in plasticity mechanisms across different timescales.

This study investigates how psilocybin affects cortical and behavioral activity in mice, finding biphasic effects on neural responses and behavior.

This study uses zebrafish behavior tracking to show psilocybin increases rapid swimming and prevents stress-induced irregular swimming, suggesting stimulatory and anxiolytic effects.

This study examines how external stimuli modulate brain entropy during a psychedelic experience, finding that eye closure enhances entropy changes and that video stimuli disrupt the relationship between brain activity and subjective experience.

The paper identifies brain regions and networks predictive of response to psilocybin therapy for treatment-resistant depression using whole-brain modeling and dynamic sensitivity analysis.

This study shows nitrous oxide reduces functional differentiation in brain networks and correlates with psychedelic experiences.

This study shows psilocybin improves cognitive flexibility and body weight in female rats with activity-based anorexia, mediated by 5-HT1A and 5-HT2A receptor mechanisms.

This paper uses brain-fingerprinting to show that psilocybin increases idiosyncratic functional connectivity in the default-mode network, which predicts subjective drug experiences.

This study shows that psychedelics suppress intrinsic excitability of prefrontal pyramidal neurons via M-current channels, independent of 5-HT2AR activation, and reduces working memory timespan.