Vagus Nerve Stimulation Research

This study shows that vagus nerve stimulation (VNS) enhances motor learning in mice when paired with successful movement, but impairs learning when random, suggesting it reinforces outcome cues through cholinergic signaling.

This study develops a decoding algorithm to identify cardiovascular and respiratory changes from vagus nerve signals in pigs, achieving high accuracy and introducing a new performance index.

This study examines how brain state affects cortical responses to vagus nerve stimulation in non-human primates, finding that certain components of the response vary with brain state and stimulation frequency.

This study investigates how acute vagus nerve stimulation (VNS) affects auditory learning and neural activity in ferrets over 1-2 days, finding increased learning rates and specific neural response reductions in primary auditory cortex.

This study uses pupil dilation as a biosensor to assess real-time effects of vagus nerve stimulation on brain state in mice.

This study shows that non-invasive vagus nerve stimulation improves positive mood after physical and cognitive exertion, with effects dependent on baseline mood.

The paper uses single-cell transcriptomics to analyze DMV neuronal states under homeostasis and after cardiac ischemic injury, revealing shifts in input-output signal processing and regulatory microRNAs.

This study demonstrates selective cervical vagus nerve stimulation using flexible cuff electrodes to target abdominal pathways while minimizing cardiovascular side effects in a rat model.

This study shows that transcutaneous vagus nerve stimulation (tVNS) in humans causes pupil dilation and reduces alpha oscillations, suggesting it mimics invasive VNS effects on arousal and neuromodulation.

This study shows that transcutaneous auricular vagus nerve stimulation (taVNS) increases vigor for rewards, particularly for food, but not effort maintenance, with left-side stimulation having a stronger effect.

The paper identifies specific neuroanatomical pathways causing off-target effects of vagus nerve stimulation in pigs and characterizes dose-response curves for on- and off-target effects.

This study shows that vagus nerve stimulation impairs reinforcement learning by reducing the learning rate, particularly after punishment, in a go/no-go task.

The paper optimizes microCT protocols to segment and track fascicles in rat sciatic and pig vagus nerves, aiming to improve VNS targeting and reduce off-target effects.

The paper identifies a unique transcriptional signature in airway-innervating JNC neurons after LPS-induced lung inflammation, revealing their distinct response to injury.

This study examines how chronic cardiac ischemia alters the transcriptional phenotype of neurons in the dorsal motor nucleus of the vagus in rats, showing a shift towards a neurosecretory phenotype.

The paper characterizes the anatomy of the cervical vagus nerve in domestic pigs, identifying structural features relevant to vagus nerve stimulation and comparing them across species.

This study shows that non-invasive vagus nerve stimulation reduces gastric frequency without affecting resting energy expenditure.

This study shows that cervical vagus nerve stimulation increases cerebrospinal fluid penetration into the brain, suggesting potential clinical implications for CNS disorders.

This study shows noninvasive vagal nerve stimulation reduces neural and physiological responses to noxious thermal stimuli by modulating pain and autonomic circuits.

This study uses fMRI to show that vagus nerve stimulation activates 15 out of 20 brain networks in rats and alters large-scale functional connectivity.