RNA regulation and disease

The paper identifies genetic variants influencing A-to-I RNA editing in neurodegenerative diseases using large-scale transcriptomic and genetic data from multiple brain tissues.

This study shows that Adar1 deletion in mice causes exocrine pancreas degeneration through Mavs-dependent interferon signaling, which is rescued by concurrent Mavs deletion.

The paper examines RNA editing changes during human cortical development, identifying expansion of editing sites and their genetic regulation linked to neurological disorders.

This paper introduces CellREADR, a programmable RNA sensing technology that detects and manipulates cell types via RNA editing, demonstrating its use in mouse and human brain tissues.

The paper quantifies RNA editing in human brain cell types, identifies cell-specific editing sites, and discovers cis-editing quantitative trait loci linked to genetic regulation.

The paper identifies three types of A-to-I editing site clusters in cephalopods and describes structural features and mechanisms underlying their formation.

This study engineers ADAR2 deaminase variants to enhance RNA editing activity, specificity, and functionality through deep mutational scans, domain-wide mutagenesis, and split deaminase design.

The paper shows that ADAR2-mediated RNA editing of DNA:RNA hybrids is essential for DNA double strand break repair by facilitating DNA end resection.

The paper identifies RNA editing sites in single cortical neurons and links locus 15q11 with psychiatric illness through differential editing in cell types.

This paper develops RT-qPCR assays to distinguish A-to-I-edited microRNA isoforms, showing their utility in detecting biomarkers in prostate cancer.

RESIC identifies and classifies A-to-I RNA editing sites across organisms and datasets, showing increased hyper-editing and ADAR1 activity in SARS-CoV-2 infected cells.

MultiEditR is a tool that detects and quantifies RNA editing from Sanger sequencing, offering a cost-effective validation method for RNA editing sites.

The paper identifies 177 C-to-U RNA editing events in murine transcripts, analyzes cis-acting sequence features and trans-acting factors, and develops a predictive model for editing efficiency.

The paper develops a CRISPR-based mutagenesis approach combined with machine learning to model cis-regulatory features of ADAR-mediated RNA editing, explaining over 70% of editing level variation.

AIDD is a pipeline that automates RNA-seq analysis to detect transcriptome diversity, including RNA editing, and provides publication-ready results.

The paper identifies ADAR-mediated RNA editing sites in Drosophila proteomes across developmental stages and shows editing is phase-specific and enriched in synaptic and actomyosin functions.

HPC-REDItools improves RNA-editing analysis by enabling faster processing of large datasets using MPI-based parallel computing.

This study uses RNA base editing to repair a mutation in a mouse model of Rett syndrome, restoring MeCP2 function in hippocampal neurons.

The paper identifies RNA editing signatures in SARS-CoV-2 transcriptomes, suggesting host deaminases like ADAR and APOBEC contribute to antiviral defense and viral evolution.

The paper identifies Zn72D as a regulator of ADAR-mediated RNA editing in Drosophila neurons and shows its conservation in mammals.

The paper identifies trans regulators of ADAR1 and ADAR2 using BioID and mass-spectrometry, validating novel interactors as RNA editing regulators.

The paper identifies genes associated with A-to-I RNA editing in four cancers using a logistic regression model and highlights cancer-specific and shared regulatory patterns.

The paper identifies ADARs and the ERI-6/7/MOV10 RNAi pathway as factors silencing endogenous viral elements and LTR retrotransposons in C. elegans, with implications for genome integrity and stress responses.

The paper introduces a method to selectively isolate A-to-I edited transcripts using Endonuclease V under Ca2+ conditions, improving sensitivity and accuracy for detecting RNA modifications.

This study shows that fluoxetine alleviates alcohol addiction by reducing RNA editing of 5-HT2C receptors in astrocytes, thereby increasing ATP release and improving behavioral symptoms.

The paper compares RNA editing in ADAR mutant mice to determine site-specific regulation by ADAR1 and ADAR2.

The paper integrates RNA-Seq datasets to map RNA editing sites during mouse spermatogenesis, revealing their genomic distribution and functional impact.

This study identifies RNA editing sites in eight chicken tissues, finding 68 novel sites and highlighting tissue-specific genes associated with functional processes.

The paper identifies and analyzes A-to-I RNA editing events in radiation-induced malignantly transformed cells, finding that SNPs affect ADAR2 activity and contribute to cancer progression.

The paper investigates changes in ADAR1 and ADAR2 mRNA expression in congenital heart defect patients and finds opposite expression patterns, suggesting ADAR2 may prevent cardiovascular defects.