Studies on Chitinases and Chitosanases

The paper investigates the structural and chemical properties of chitin in insect extracellular matrices, finding that PM chitin is highly acetylated and organized as dihydrate β-chitin, while cuticle chitin is deacetylated and structured as α-chitin.

The paper introduces a 'bait-and-switch' strategy to link enzyme function with community-level phenotypes in microbiomes, demonstrating its feasibility in identifying chitin-degrading enzymes.

The paper functionally characterizes multi-domain LPMOs from marine Vibrio species, revealing that domain-domain interactions modulate enzyme activity by regulating copper site accessibility.

The paper generates a Ym1 deficient mouse using CRISPR-Cas9 in CB6 embryos and validates the absence of Ym1 protein without affecting related chitinase genes.

This study models the catalytic mechanism of human chitotriosidase-1 using structural data and simulations, and shows how the OATD-01 inhibitor disrupts enzyme function through dynamic changes.

This study expresses and characterizes the chiA chitinase gene from Serratia marcescens GBS19, showing it has insecticidal activity against Myzus persicae with high similarity to reference sequences and strong chitin binding.

This study investigates the mechanisms of chitin degradation in aquatic chytrids, finding expanded glycoside hydrolase genes and adaptive secreted chitinases that facilitate saprotrophy.

This study introduces a method using microbial enzyme cocktails to quantify polysaccharides, demonstrating effectiveness for chitin and laminarin with low detection limits.

This study shows two Aeromonas strains can degrade and use chitin as a carbon and nitrogen source, revealing their metabolic potential in nutrient-poor environments.

The paper investigates the expansion and functional diversification of chitinase and chitin synthase genes in Atlantic salmon using comparative genomics, transcriptomics, and chromatin accessibility data.

The paper investigates the roles of Expansion/Rebuf and Krotzkopf Verkehrt in chitin deposition in Drosophila, showing their distinct functions in polymerization and translocation.

This study identifies Drosophila CLPs as Imaginal disc growth factors with roles in fertility, viability, epithelial morphogenesis, and CO2 response.

The paper characterizes four chitin deacetylase genes in the Diaphorina citri genome, providing a foundation for future studies on their potential roles in exoskeleton formation and bacterial defense.