Moyamoya disease diagnosis and treatment

This study identifies dysregulated proteins in serum-derived exosomes from Moyamoya disease patients, linking them to angiogenesis and vascular signaling pathways.

The paper uses spatial transcriptomics and functional experiments to show SULF1 enhances VEGFR2 signaling and vascular remodeling in Moyamoya Disease.

This study uses spatial multi-omics to show ECM remodeling and VSMC phenotypic switching in Moyamoya Disease, linking FN1-ITGA5-FAK pathway activation to metabolic changes in the intimal niche.

This study shows miR-486-3p improves angiogenesis in Moyamoya disease by targeting FOXO4 to reduce senescence-associated secretory phenotype.

This study identifies the Arg4810Lys RNF213 variant in Eastern Indian non-MMD ischemic stroke patients, finding its association with family history, earlier onset, and recurrent stroke, but not cognitive decline.

This paper describes a novel surgical procedure, encephalomyosynangiosis, for ischemic stroke in mice and shows it does not increase mortality and maintains graft viability.

The paper investigates RNF213 variation's role in neurovascular diseases across Caucasian and Japanese populations, finding linkage disequilibrium between SLC26A11 and RNF213 variants associated with ischemic stroke and aneurysms.