Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology

Chromatin Remodeling and Cancer

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

Cancer Biology·PLoS Computational BiologyPeer-reviewed·Aug 27, 2026
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Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability
Luisa Quesada Camacho, Mohammad Fallahi‐Sichani
Complex-level DepMap dependency modeling across 42 cancer types nominates Set1C/COMPASS as melanoma-enriched; CXXC1 knockdown lowers H3K4me3, curbs proliferation, and suppresses MYC/E2F programs in responsive melanoma lines.
DOI 10.1371/journal.pcbi.1014018
human·CRISPR screen
·𝕏 Post·Bluesky