Systems BiologyiSciencePeer-reviewed
Topic · Cardiology and Cardiovascular Medicine · Medicine
Cardiovascular Disease and Adiposity
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
5 papers
- BioengineeringAdvanced SciencePeer-reviewed
3D Bioprinted Fat-Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction
Lara Ece Celebi, Pınar Zorlutuna
This paper develops a 3D bioprinted model of fat-myocardium to study how adipocyte hypertrophy contributes to atrial dysfunction in obesity and shows metformin improves electrophysiological function.
5 citationstop 1% - PhysiologySciencePeer-reviewed✦ In-depth digest
Ablation of Prdm16 and beige fat causes vascular remodeling and elevated blood pressure
Mascha Koenen, Tobias Becher, Giulia Pagano…·Paul Cohen
Adipocyte-specific deletion of Prdm16 ablates beige fat identity, derepresses the secreted enzyme Qsox1, and induces vascular fibrosis, angiotensin II hyperreactivity, and elevated blood pressure in mice.
- PhysiologyJournal of HypertensionPeer-reviewed
Perivascular adipose tissue remodeling impairs vasoreactivity in thermoneutral-housed rats
Melissa M. Henckel, Ji Hye Chun, Leslie A. Knaub…·Amy C. Keller
This study shows that thermoneutral housing causes perivascular adipose tissue remodeling in rats, leading to sex-dependent impairments in vasoreactivity and mitochondrial function.
4 citations - Molecular BiologyAmerican Journal of Physiology-Heart and Circulatory PhysiologyPeer-reviewed
A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers
Janice Thompson, Stephanie Wengert Watts, Leah Terrian…·Rance Nault
The paper uses snRNAseq to analyze thoracic aortic perivascular adipose tissue (taPVAT) and subscapular brown adipose tissue (BAT) in rats, identifying cell-specific gene expression and highlighting PIEZO1 as a key mechanotransducer in taPVAT.