Digestive system and related health

CDX2 Drives Divergent Regional Programs During Intestinal Development and Redeploys Them During Regeneration

This study shows CDX2 organizes enhancer networks during intestinal development and regeneration, reusing fetal and adult programs to restore regional identity.

APOA1 links a late fetal epithelial program to colonic maturation and injury responses

This study identifies APOA1 as a marker of a late fetal colonic epithelial state that reappears after injury, linking it to colonic maturation and injury responses through interactions with WNT5A and regulation by HOXB7.

Diverse Intestinal Injuries Drive Heterogeneous Transcriptional Responses and Limited Reactivation of Developmental Gene Programs in Human Enteroids

This study examines how human enteroids respond to various injuries, finding limited reactivation of developmental gene programs and highlighting the role of specific signaling pathways.

Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience

This study shows that fetal reversion from diverse lineages sustains the intestinal stem cell pool and enhances stress resilience through bidirectional interconversion between CBCs and revSCs.

Revisiting the Evolution of Lactase Persistence: Insights from South Asian Genomes

This study analyzes South Asian genomes to understand the evolutionary history of lactase persistence, finding that Steppe ancestry, not selection, explains most LP prevalence, with exceptions in two pastoralist groups.

Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development

The paper uses single-cell transcriptomics to study EEC lineage dynamics and gene regulatory networks during intestinal development in mice and humans, finding that most EECs are specified during development independently of crypt-villus structures and microbiota.

BEST4/CA7+ and goblet cells are interdependent regulators of intestinal mucus homeostasis

The paper shows that BEST4/CA7+ cells and goblet cells depend on each other for survival and differentiation in the intestinal mucus layer.

Acute tuft cell ablation induces malabsorption and alterations in secretory and immune cell lineages in small intestine

This study shows that acute tuft cell ablation in mice causes malabsorption and changes in secretory and immune cell lineages in the small intestine.

Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

A Human Biomimetic Intestinal Mucosa Model to Study Gastrointestinal Development and Disease

This paper develops a human intestinal mucosa model incorporating epithelial, fibroblast, and antigen-presenting cells to study intestinal development and disease mechanisms.

A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin

The paper identifies MTA2 and SATB2 as a chromatin complex that maintains colonic identity by retaining HNF4A on colonic chromatin, preventing plasticity toward small intestine.

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains

The paper identifies five discrete metabolic domains in the mouse and human small intestine using transcriptional signatures and machine learning, showing how diet influences domain properties.

ARID3A coordinates the proliferation-differentiation switch of transit-amplifying cells in the intestine

This study identifies ARID3A as a regulator of intestinal epithelial cell proliferation and differentiation, showing its role in maintaining tissue homeostasis through modulation of TA cell dynamics.

The Role of Lrig1 in the Development of the Colonic Epithelium

This study investigates the role of Lrig1 in colonic epithelial development, showing it supports stem cell behavior and crypt formation in mice.

Comparison of human and mouse fetal intestinal tissues reveals differential maturation timelines.

This study compares human and mouse fetal intestinal tissues to show differences in maturation timelines, with most human maturation events occurring postnatally.

The genetic variation of lactase persistence alleles in northeast Africa

The paper examines lactase persistence allele frequencies in Sudanese and South Sudanese populations, finding higher LP-associated alleles in pastoralists and identifying the -14009:G variant as the most frequent.

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

This study identifies Rfx6 as a key regulator of enteroendocrine cell differentiation, promoting peptidergic cells while repressing serotonin-producing cells.