Go Ito

This study shows that fetal reversion from diverse lineages sustains the intestinal stem cell pool and enhances stress resilience through bidirectional interconversion between CBCs and revSCs.

This study investigates long-term intestinal epithelial changes after acute protein-energy malnutrition using multi-omics approaches and identifies microbial lipid metabolites and epigenetic factors as key drivers of persistent Paneth cell dysfunction.

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

This study performs a genome-wide association analysis of hemorrhoidal disease in 944,133 individuals, identifying 102 risk loci and linking them to vascular and tissue development pathways.

The paper presents a method to deplete dominant miRNAs from blood-derived RNA samples, improving detectability of low-abundance miRNAs in small RNA sequencing.