Immunotoxicology and immune responses

The paper evaluates six alveolar macrophage models to identify those best representing in vivo AMs for assessing nanomaterial toxicity, finding AMs GTR and BM-AMs most suitable.

This study investigates the hormetic effects of DNCB on THP-1 cells, showing increased metabolic activity at low doses and reduced immune marker expression at higher doses.

This study shows that low cadmium exposure alters B and T cell gene expression in Jamaican fruit bats, suggesting immune system changes, but not affecting viral replication in kidney cells.

This study shows ovarian hormone deficiency increases vulnerability to wood smoke-induced immune disruption in bone marrow by altering transcriptional and metabolic programs in macrophages.

This study shows that environmental materials damage macrophage plasma membranes, reducing ROS and phagocytosis while increasing cell fusion and impairing immune responses.

This study examines the immediate and delayed effects of juvenile doxorubicin exposure on thymic immune cell populations and gene expression in mice, revealing thymic atrophy and immunosenescence.

This study assesses the 4-week immunotoxicity and toxicokinetics of lactoferrin alpha produced by Komagataella phaffii in rats, finding no toxicologically significant changes at high doses.

This study uses RNA sequencing to analyze immune gene responses in macrophages exposed to bleomycin, identifying dose-dependent gene alterations and linking them to cytokine and proteinase activity.

This study uses single-cell RNA sequencing to show that chronic methamphetamine exposure alters liver immune cell composition and function, with involvement of the dopamine D1 receptor.

This study identifies 33 gene biomarkers for drug-induced vascular injury in rats using gene expression and histopathology data from treated animals.