Discover, rate, and discuss biology preprints.

This study measures human connective tissue distribution and characterizes its material properties using data from the Visible Human Project.

This paper introduces a quick, robust, xeno-free/serum-free method to generate human iPSC-derived choroid plexus organoids for studying CSF dynamics and brain barrier function.

This study develops a multi-channel SCOS system to map human cerebral blood flow changes during brain activation, showing spatial heterogeneity and validating its accuracy with a phantom.

The paper introduces an accessible platform to measure oxygen diffusion in cell-laden hydrogels and applies it to alginate-immobilized pancreatic beta cells, showing reduced diffusion coefficients with higher gel concentration.

This paper introduces a hydrogel-based method to pattern dissociated neurons into multi-scale networks, showing that connectivity paradigms influence ensemble dynamics.

This study shows that slow stress-relaxing matrices promote greater mammary branching morphogenesis compared to fast stress-relaxing matrices.

This study develops an additively manufactured carotid artery model to simulate sickle cell disease vasculopathy, validated with clinical imaging and mechanosensitive cells.

This study develops and tests a SilkMA-Gelatin ink for 3D bioprinting, showing improved cytocompatibility, structural stability, and in vivo biocompatibility for tissue regeneration.

This study develops an anisotropic reactive viscoelastic model of the rhesus macaque cervix to understand its time-dependent remodeling during pregnancy and its implications for preterm birth.

This study shows that cold atmospheric plasma (CAP) modulates Alzheimer's disease progression in mice by enhancing neuroimmune signaling without causing harm in healthy mice.

This paper develops a wireless bioelectronic actuator for wound healing in pigs, showing reduced M1/M2 macrophage ratio and increased re-epithelialization in treated wounds.

PRECISE, a long-acting immunosuppression platform, maintains therapeutic drug levels and prolongs graft survival in VCA models through precise control of tacrolimus and rapamycin release.

The paper compares the effects of eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance, finding significant differences in particle properties and performance across methods.

The paper compares manual and semi-automated cell counting methods, finding the semi-automated method has better repeatability for total cell density but similar results for cell viability.

This paper develops engineered FVIII variants for hemophilia A gene therapy, showing improved secretion, coagulation activity, and efficacy at lower vector doses in mice and macaques.

This paper develops a deep learning framework for automated segmentation of 3D CT data and validates its biomechanical accuracy using zebrafish mandibles.

The paper develops and evaluates qPCR and qLAMP assays for detecting BAV-7, achieving high specificity and agreement, with qLAMP showing potential for field use.

This study engineers recombinases to improve DNA insertion efficiency and specificity in human cells, achieving 53% integration and 97% genome-wide specificity.

This paper introduces adjustable compliance footwear to study gait adaptation during treadmill and overground walking, demonstrating its ability to rapidly change midsole compliance and measure sole deflection.

HyperBind2 improves antibody discovery through multi-shot learning, achieving higher accuracy with iterative lab-AI feedback cycles and reducing experimental burden.