Discover, rate, and discuss biology preprints.

This paper introduces CLIC, a novel method for thrombolysis that removes clots more efficiently than existing techniques, with a mass-loss rate 40-fold higher and reduced embolic risk.

This paper develops a method to create bioelectronic interfaces using collagen and conducting polymers, enhancing biointegration and cell compatibility.

This paper introduces LIT, a method to predict and detect anomalies in 2PP fabrication quality in real-time, without needing post-processing labels.

This paper introduces a method to detect multiple molecular classes using nanopore sequencing by encoding targets into periodic DNA barcodes, achieving high specificity and error tolerance.

This study develops a bioprinted artery-on-a-chip model to study inflammatory responses and test drug efficacy in human arteries.

This study examines sex differences in aortic remodeling after antihypertensive treatment in rats with gradually developed hypertension, finding more effective reversal in females.

This study humanizes and engineers infliximab to improve its potency and developability, identifying LW2Y as a lead candidate with enhanced pH-dependent properties.

This paper reframes substrate crossover in microbial fuel cells as a design variable to sustain microbial metabolism and improve long-term operation.

This paper evaluates the use of Pluronic F127 coating to enhance spheroid formation in microwells by reducing cell-substrate adhesion.

The paper compares the proteomic composition of decellularized extracellular matrix (dECM) and dECM-based inks to native tissues, finding increased collagen proportions in inks and a core matrisome shared across all dECMs.

This study develops a rocking bioreactor system to enhance pro-angiogenic factor secretion by hASCs through dynamic culture and DAT coatings.

This paper re-examines the lower speed boundary of preferred coordination ratio constancy using published data, finding competing breakpoint regions rather than a single dominant boundary.

This paper develops SONATA, a nanobubble-based ultrasound-guided immunotherapy that activates the STING pathway in breast cancer, showing tumor growth inhibition and improved survival in mice.

This study examines how nanostructured zirconia thin films affect glial calcium signaling in astrocytes and neuron-glia co-cultures, showing enhanced glial responses compared to flat substrates.

This study benchmarks sensory properties of dairy and dairy-free products across ten categories, finding significant gaps in mozzarella, Greek-style yogurt, and butter.

The paper discovers that wild-type curli nanofibers have intrinsic antifungal activity and shows that fusing them with heliomicin enhances this activity against Candida albicans.

This paper demonstrates that 2-arm-PEG-oligocations transiently shield liver sinusoids to reduce off-target hepatic mRNA expression and improve iLNP delivery to spleen and tumors.

This paper introduces an implantable poly(pro-curcumin) film that provides long-lasting neuroprotection after spinal cord injury by locally delivering curcumin, improving locomotor recovery and reducing inflammation.

This study evaluates how static, slow, and fast dynamic scatterer components affect the flow index measured by cw-DCS, showing significant underestimation when static and slow components are present.