Brianne K. Connizzo

This study examines age- and sex-related differences in inflammatory crosstalk between bone, tendon, and muscle tissues in mice, finding altered cytokine secretion and communication patterns with aging.

This study investigates how mechanical strain affects tendon ECM remodeling, finding that increased strain promotes anabolic remodeling via TGF-β and IL-6 signaling, while decreased strain leads to catabolic changes.

This paper develops an ex vivo method to measure supraspinatus muscle function in mice and shows age and injury affect contractility.

This study investigates sex differences and the roles of estrogen and progesterone in tendon extracellular matrix remodeling using an explant model of mouse tendons.

This study uses an ex vivo laser-induced microdamage model to show that tendon cells can clear microdamage regardless of size, with larger injuries showing more robust clearance over time.

This study investigates how glucose and glutamine metabolism changes with aging in tendon tissue and its impact on extracellular matrix remodeling.

The paper quantifies transposable element RNA dynamics in aging human and mouse brains and neurodegenerative diseases, finding age-related changes and disease-specific TE RNA dysregulation.

This study shows that cellular senescence impairs tendon ECM remodeling under mechanical unloading, contributing to age-related tendon dysfunction.

This study investigates how aged tendons respond to mechanical strain, finding reduced adaptability and a shifted mechanical setpoint compared to young tendons.