Discover, rate, and discuss biology preprints.

This paper introduces a cuffed guide RNA (cgRNA) that enables miRNA activity-dependent genome editing in human and mouse cells.

This paper develops a DNA hydrogel that rapidly stops bleeding and promotes tissue regeneration in mice by combining hemostasis with bioactive properties.

This study demonstrates hydrogen-driven cofactor regeneration for efficient pyruvate-to-lactate conversion using engineered enzymes.

This study evaluates the risk of a recombinant plant rhabdovirus, MMV-GFP, compared to its wildtype MMV-WT, finding it less fit and posing no greater risk to crops or ecosystems.

This study shows how PEG hydrogel formulation affects the accumulation of proteins and nanoparticles, with larger molecules requiring more permissive formulations.

ContiDesigner is a tool for designing continuous fermentation cascades that identifies optimal operating conditions to maximize productivity.

This paper demonstrates the biosynthesis of diverse retinal analogues in engineered E. coli using Blh, a carotenoid cleavage enzyme, through substrate promiscuity and structure-guided engineering.

The paper quantifies variability in temporal interference simulations caused by non-deterministic mesh generation and shows that multi-run averaging reduces this noise.

This paper introduces a closed-loop optical platform for precise retinal stimulation in mice, achieving high-resolution patterned stimulation with real-time focus correction.

The paper constructs a prior photon measurement density function (PMDF) using a standard channel space and structural MRI database, outperforming template-based PMDF in fNIRS studies.

This study shows HYAL1 suppression in glioma cells increases invasion by altering ROS levels and adhesion molecule expression in 3D hyaluronic acid matrices.

This study uses volumetric bioprinting to enable post-printing optogenetic stimulation of cells within hydrogel constructs, demonstrating spatial control over light-responsive proteins and gene expression.

This paper develops nanodiscs for targeted delivery of an anti-inflammatory drug to macrophages in AAA, showing reduced disease progression in mice.

This study develops submicron phosphatidylserine-exposing polymeric particles (PSPs) that modulate macrophage activity by reducing inflammation and promoting resolution through redox adaptation and suppression of inflammatory signaling.

This paper develops a colorimetric hydrogel dressing that uses a smartphone camera to monitor wound pH in real-time, enabling point-of-care diagnostics for chronic wounds.

This paper develops a closed-loop vibrotactile stimulation system to reduce tremor amplitude and propranolol use by modeling a nonmonotonic tremor-vibration relationship.

This study investigates the role of phosphate and carbonate in the biomineralization of bivalve shells, identifying phosphate as the primary phase and carbonate as a secondary phase in Limnoperna fortunei.

This paper introduces sDNA-PAINT, a method that improves spectral precision and multiplexing in super-resolution microscopy using DNA Origami Nanorulers and spectroscopic SMLM.

The study tests if a crossmodal congruency task can measure the intuitiveness of sensory feedback in lower limb prostheses, finding it effective at the knee but not the foot.