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This paper presents a device for adapting upright light sheet fluorescence microscopy to image samples at air-liquid interface, demonstrating its use on three biological specimens.

Electrical activation of piezoelectric nanoparticles reversibly opens the blood-brain barrier for minimally invasive drug delivery to targeted cortical regions.

This paper introduces a lysis-independent method for joint host-pathogen single-cell profiling using bacterial surface display, enabling analysis of both host and pathogen features in infected cells.

This study shows that polyvinylpyrrolidone (PVP) enhances AAV transduction in vitro and improves subretinal delivery in vivo.

The paper develops an LDLR-independent LNP platform for hepatocyte-targeted mRNA delivery and validates an LDLR-knockout HepG2 model for studying LDLR biology.

This study investigates the acute effects of static magnetic fields on excitatory synaptic activity in rat motor cortex neurons using patch-clamp recordings.

This paper develops a digital microfluidic platform that enables simultaneous short- and long-read viral genomic surveillance with improved efficiency and accuracy.

This paper identifies a camelid single-domain antibody that inhibits T. brucei enolase and elucidates its inhibitory mechanism using biochemical, biophysical, and structural methods.

This paper develops a genetic part library for constructing tunable dsRNA circuits in C. elegans to enable precise RNA interference.

This study develops a multiscale computational model linking TMJ structural changes to nociceptive activation by integrating biomechanics, neural morphology, and electrophysiology.

This paper introduces a post-loading method for mRNA into lipid nanoparticles to reduce cold storage requirements, achieving comparable delivery efficiency to conventional methods.

This paper develops threshold-free deep learning models for detecting swim bouts in larval zebrafish, showing improved precision over traditional methods and revealing behavioral patterns across genetic backgrounds.

The paper introduces RASPBerry, a hydrogel-based spatial barcoding platform for time-lapse flow cytometry, enabling tracking of suspended cells with high accuracy and throughput.

This study introduces a tunable laminar perfusion system for vasculature-on-chip to study sustained flow effects on vascular remodeling and immune interactions.

This study enhances cyanobacterial photosynthetic hydrogen production by addressing multiple metabolic constraints, achieving higher yields but also revealing trade-offs with metabolic stability.

This paper develops a thermodynamic continuum model of tumour spheroid growth that recovers multicompartment structure and supports drug-response screening without prescribing compartments.

The paper investigates the role of microbial influenced corrosion (MIC) in causing spine rod fractures by analyzing tissue samples from patients with titanium implants.

This paper identifies critical process parameters for producing stable, uniform coated nanobubbles via mechanical agitation.

This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.

This study shows that soft hydrogels promote tertiary lymphoid structure formation, while stiff hydrogels hinder it, improving antitumor immunity.