Discover, rate, and discuss biology preprints.

This study presents cryo-EM structures of MBOAT2, revealing its catalytic mechanism, product retention, and ligand exchange dynamics.

This study identifies surface tension and stalk elongation as key mechanical drivers of fruiting body formation in Dictyostelium discoideum using a hydrodynamic model and experimental measurements.

The paper integrates ion mobility spectrometry with HDX/MS to better resolve conformational ensembles in DNA oligonucleotides, showing improved kinetic analysis and distinction of non-specific cation binding.

This study shows CRISPR-dCas13d can repress VEGF translation by destabilizing its G-quadruplex IRES under hypoxia, without affecting mRNA levels.

This study shows influenza A virus actively transports itself by modifying its environment, using its envelope proteins to create directional cues and bias movement.

The paper uses STED microscopy to study CENP-A organization during mitosis in human cells, finding stage-dependent spatial variations in its structure.

The paper uses SEIRAS to show that membrane charge affects the secondary structure of poly-GR condensates at the membrane interface.

The paper reports a cryo-EM structure of a 95-basepair DNA minicircle at 5.3 Å resolution, revealing its B-DNA configuration and structural features.

The paper introduces a metric to quantify the trade-off between dissipation and construction cost in adaptive transport networks using a single value derived from network architecture.

The study uses molecular dynamics simulations to show that wild-type hERG fails to conduct K+ and evolves toward an inactivated-like conformation, contrasting with the N629D mutant which maintains conductivity.

This paper identifies DNA aptamers that bind the truncated form of HasA, a hemophore in Pseudomonas aeruginosa, under acidic conditions, showing potential as antimicrobial agents.

This paper demonstrates the isothermal assembly of DNA nanostructures and 3D crystals in hydrated ionic liquids, enhancing biostability and enabling cell internalization without thermal annealing.

This study reports cryo-EM structures of comammox AMO from Nitrospira inopinata and identifies its catalytic and inhibitor-responsive architecture, revealing a methyl-PQ-linked mechanism and stress response to nitrification inhibitors.

The paper derives a formula for tumor expansion speed based on cell movement and growth rates and validates it along white-matter tracts using diffusion tensor imaging.

This study uses molecular dynamics simulations to show how pH and temperature together destabilize dengue virus envelope dimers, revealing a 'compensatory embrace' mechanism and potential targets for antiviral drugs.

The paper uses polarized neutron scattering to study individual and collective fast dynamics in proteins, highlighting challenges in analyzing coherent scattering contributions.

This study uses enhanced sampling simulations to analyze A22-actin interactions, revealing binding affinities, residence times, and unbinding kinetics across multiple sites.

OpenFPM provides an open-source, low-cost Fourier ptychographic microscopy platform for high-resolution biomedical imaging.

The paper estimates current-voltage characteristics of K+ channels using Markov State Models from MD simulations, showing agreement with direct simulations at low potentials.

This study shows that protein-protein interactions can follow static or dynamic binding paradigms, with distinct temperature dependencies and mechanisms affecting affinity prediction.