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This paper introduces a crossed laser phase plate (xLPP) for cryoEM, demonstrating improved contrast and resolution in imaging biological samples.

This paper introduces Brightness Demixing, a method for distinguishing multiple fluorophores in SMLM by using brightness instead of spectral separation, enabling multi-target imaging in 2D and 3D.

This paper introduces Tether Force Spectroscopy (TFS), a bead-free single-molecule force spectroscopy method that enables high-throughput, high-resolution measurements of biomolecular conformational dynamics with internally calibrated forces.

The paper shows how stochastic dynamics and cytoskeletal regulation shape distinct neuronal morphologies in Drosophila mechanosensory neurons.

The paper decodes energetic blueprints of conserved protein folds to explain functional diversity and enables engineered transcription factors with ligand-driven responses.

This paper introduces a latent interaction landscape from Micro-C data that captures chromatin regulatory identity and structural diversity beyond contact frequency.

The paper shows that a single generative program produces both network and wave phases in C. elegans, with differences arising from environmental context rather than behavioral rules.

This paper uses machine learning to classify subcellular organelles from infrared images, achieving accurate identification of several organelles but not all.

This paper presents a correlative imaging platform combining fluorescence microscopy and scanning SAXS to study cellular structures in native conditions, showing agreement between label-free SAXS and labeled fluorescence data.

This paper introduces a Bayesian method to interpret time-resolved experiments using molecular simulations, demonstrating its application to protein unfolding studies.

This study uses molecular dynamics simulations to investigate how the intrinsically disordered regions of FUS recognize U1 snRNA, revealing distinct interaction mechanisms and structural changes upon RNA binding.

This paper identifies specific interfacial residues in IGPS that modulate allosteric regulation through structural and dynamic changes induced by targeted mutations.

This study investigates FoxP1 assembly and nuclear organization, revealing that its leucine-zipper and Forkhead domains antagonistically regulate complex formation and DNA binding.

This study investigates surface phase separation in confined spaces, identifying three wetting states and explaining droplet formation under specific conditions.

This study shows that Piezo1 channels in cell-derived membranes exhibit mechanical gating and adopt a flattened shape, requiring both mechanical force and a membrane-derived cofactor for activation.

The paper develops a method to image and analyze cilia-driven transport in mammalian tissues using light-field microscopy and flow reconstruction, revealing conserved flow structures across different tissues.

This study identifies four recurrent dengue envelope protein interaction architectures using computational methods and suggests viral stability depends on local network context.

This study investigates how ATP and ADP binding affects MreB polymerization and membrane interaction in Geobacillus stearothermophilus, revealing distinct binding affinities and membrane fluidizing effects.

This study investigates whether mechanical forces during collective epithelial migration can trigger cytoplasmic liquid-liquid phase separation, showing feedback effects on motility.

The paper investigates how intramolecular interactions between folded and disordered regions of ubiquilin proteins influence their structure and function across different species.