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The paper constructs high-density linkage maps for Plasmopara viticola to study recombination patterns and karyotypic variations, revealing gene-rich regions with higher recombination rates and anomalies in 5% of offspring.

The paper uses CRISPRa to activate IRD-linked genes in PBMCs to detect transcripts for improved genetic diagnosis of inherited retinal dystrophies.

The paper introduces Pantry, a framework for generating diverse RNA phenotypes from RNA-seq data and integrating them with genetic data, leading to increased gene-trait association discoveries.

The paper presents a genome-scale CRISPRi perturbation map in human pluripotent stem cells using single-cell RNA sequencing to study trans gene regulation across diverse genetic backgrounds.

This study investigates the genomic organization of AMH and AMHR2 genes in dogs with PMDS using bioinformatics and WGS data, revealing inaccuracies in current genome assemblies.

This study identifies rs3087967 as the causal variant at 11q23.1 that increases colorectal cancer risk by dysregulating POU2AF2, a key activator of tuft cell transcription.

This study compares the effects of G-quadruplex stabilization and destabilization on gene expression in human astrocytes using PDS and PhpC, revealing distinct transcriptomic and proteomic responses.

The paper tests a pharmacological chaperone's ability to rescue expression of destabilizing variants in the V2R gene, finding it effective for most variants.

This study investigates the role of Tenascin C in tendon healing after rotator cuff repair in mice, finding impaired healing and altered gene expression in TNC-deficient mice.

SimpleMating predicts and optimizes breeding crosses using genomic selection to maximize genetic gain while minimizing inbreeding in simulated maize breeding programs.

This paper introduces a statistical framework for regularized ensemble polygenic risk prediction using GWAS summary statistics, showing improved performance across traits and populations.

The paper successfully delivers CRISPR-Cas9 via a baculovirus vector to knock down AmOctβ2R in honey bee brain neurons, leading to appetite suppression.

The paper investigates how DNA repair genes influence Cas9-induced mutations by analyzing mutational outcomes across 2,838 synthetic targets in mouse cells, revealing gene-specific roles and improving predictive models.

The paper presents a Cas12a-based system using multiplexed sgRNAs to achieve efficient and specific gene knockouts in Drosophila with minimal off-target effects.

The paper identifies DOA/CLK2 as a kinase that phosphorylates Fl(2)d/WTAP to enhance m6A methyltransferase complex activity, crucial for dosage compensation and splicing regulation.

The paper investigates RNA modifications in the amphibious plant Riccia fluitans under different environments, finding correlations between modification types and transcript features.

This study identifies QTLs associated with freezing tolerance in winter faba bean using GWAS, providing genomic targets for marker-assisted breeding.

The paper shows that lack of PER in Drosophila leads to genotoxic stress in neuronal progenitors during development.

The paper identifies a gene regulatory network controlled by SNORD116 snoRNAs and predicts their targets in Prader-Willi syndrome using isogenic cell lines and computational analysis.

The paper reports on a competition to predict maize yield using genetic and environmental data, showing that diverse modeling approaches can achieve good results.