Author
Barcelona Institute of Science and TechnologyORCID 0000-0002-0086-4832Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
The paper introduces GPCR-MAPS, a method to generate high-resolution functional and allosteric maps of GPCRs, revealing modular architecture and novel allosteric pockets.
The paper tests a pharmacological chaperone's ability to rescue expression of destabilizing variants in the V2R gene, finding it effective for most variants.
Taylor L. Mighell, Ignasi Toledano, Ben Lehner
The paper introduces SUNi mutagenesis, a method for generating variant libraries with high scalability and uniformity to enable MAVEs of gene families and genomes.
Taylor L. Mighell, Andrew Nishida, Brendan L. O’Connell…·Brian J. O’Roak
The paper introduces Cas12a-Capture, a low-cost, scalable targeted sequencing method that reduces GC bias and improves variant calling accuracy.
Taylor L. Mighell, Stetson Thacker, Eric J Fombonne…·Brian J. O’Roak
This study combines deep mutational scanning data with clinical data to link PTEN variants to specific clinical outcomes and risk levels.
Taylor L. Mighell, Sara Evans-Dutson, Brian J. O’Roak
The paper uses a saturation mutagenesis approach in a yeast model to assess PTEN variants' impact on lipid phosphatase activity, identifying functional scores for 7,244 variants and reclassifying some ClinVar unclassified variants.