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The paper shows that anchoring H3K9-methylated heterochromatin to the nuclear periphery is necessary for P-cell nuclear migration through constrictions in C. elegans, independent of the LINC complex.

This study examines how dup15q affects gene expression and chromatin accessibility in specific brain cell types, finding cell-type-specific effects and distinct regulatory mechanisms in ASD and dup15q.

The paper identifies a conserved C-terminal region in AtrR that is required for gene-specific activation of abcG1 and other membrane transporter genes but not cyp51A, revealing distinct mechanisms of AtrR-mediated transcription.

This study shows that TREX1 mutations in the polyproline motif destabilize the protein, leading to excessive cGAS-STING signaling and autoimmune disease.

This study shows that heterologous HSPC transplantation reduces neuroinflammation and improves peripheral symptoms in a mouse model of MPS IIIC, but does not correct lysosomal storage in neurons.

The paper uses a pseudotyped virus infection assay to assess how SARS-CoV-2 variants interact with ACE2 receptor variants across species, revealing structural and compatibility shifts.

This study quantifies the fitness effects of resistance alleles to albendazole and ivermectin in C. elegans, finding that resistance requires specific gene deletions and that multi-drug resistance is not observed.

The paper shows that RAD51 DNA binding site II is essential for recombinogenic activity in Arabidopsis but not for nucleofilament formation.

This study shows that laboratory evolution can recover fitness lost in Acinetobacter baylyi strains with large deletions through mutations in deletion-specific targets and global post-transcriptional regulators.

The paper identifies gene-perturbation interactions across genetic backgrounds in yeast using CRISPRi and combinatorial DNA barcode sequencing, revealing 460 genes with variable effects and 234 interacting loci.

This study examines how ancestry and environmental factors influence de novo mutation rates and spectra in a large whole-genome sequenced cohort, finding ancestry-related effects and a link between tobacco smoke exposure and increased mutation rates.

The paper shows that HTT CAG repeats expand in striatal neurons over time, leading to gene expression changes and neurodegeneration in Huntington disease.

The paper introduces lme4breeding, a fast linear mixed model for multi-trait/multi-environment experiments that handles complex covariance structures efficiently.

This paper optimizes the SAIGE algorithm using GPUs to accelerate GWAS on large datasets, achieving 20x speedup on the Million Veteran Program data.

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

The paper identifies Indra as a negative regulator of rDNA copy number expansion in Drosophila by repressing RNA polymerase II-mediated rDNA transcription, which facilitates rDNA magnification through retrotransposon activity.

This study shows that Nab2 regulates alternative splicing and intron retention in Drosophila brain development, linking it to poly(A) tail length and gene expression changes.

The paper analyzes transcriptome data from human aneuploidies to show inverse or proportional trans-modulation of genes on unvaried chromosomes and compensation on varied chromosomes, with differences observed between autosomal and sex chromosome aneuploidies.

The paper identifies ARHGAP44 as a novel gene associated with longitudinal changes in HbA1c in non-diabetic individuals using linkage and sequence analysis from two studies.

The paper generates a high-quality genome assembly for the dyeing poison frog and shows transposable elements drive genome size evolution and complicate genotyping.