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The paper tests an extended omnigenic model to explain the geometric distribution of effect sizes in complex traits using sorghum yield data, finding evidence for regulatory effects both in space and time.

The paper investigates Alu-driven DNA transductions in primate genomes and finds no evidence of Alu-mediated transductions in humans, chimpanzees, or rhesus monkeys.

This study shows that reducing TaGS3 gene copies in wheat decreases grain size and weight in a non-additive, dosage-dependent manner, suggesting potential for improving grain yield through gene editing.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

The paper shows that heritable RNA silencing in C. elegans can occur through multiple distinct mechanisms, each detectable by unique mRNA fragment signatures.

This study uses experimental evolution of S. cerevisiae to identify genetic factors contributing to caffeine tolerance, revealing roles for multidrug resistance and TOR signaling pathways.

The paper develops eigen-polygenic risk scores (ePRSs) from clustered subnetworks of single-trait PRSs and shows they improve prediction of Alzheimer's Disease and related phenotypes.

This study benchmarks four kinship estimation tools for ancient genomes using simulated pedigrees and finds varying accuracy depending on the tool and SNP count.

The paper compares genetic variation across different geographic scales in Arabidopsis thaliana, finding that local populations contain a significant proportion of continental variation and a logarithmic relationship between genetic and geographic distance.

The paper develops a new genetic platform in Drosophila to improve spatiotemporal manipulation of histone function through CRISPR and synthetic gene arrays.

This study identifies a genomic region associated with microconidia production in Pyricularia oryzae using GWAS, suggesting potential genes involved in male fertility.

This paper introduces LIT, a method to detect latent genetic interactions using multiple traits, showing improved power compared to univariate methods in obesity-related traits.

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

This study identifies hyperactivation of innate immune signaling as a consequence of SMN depletion in Drosophila SMA models, revealing a conserved regulatory role of the SMN complex.

This study shows RPA is essential for maintaining the meiotic recombination checkpoint in yeast by sensing ssDNA and activating Mek1 kinase to regulate pachytene exit.

The paper investigates how Polycomb Response Elements (PREs) function in the ON transcriptional state, showing that PREs can still loop and interact with enhancers while some PcG proteins remain bound.

The paper identifies nuclear envelope homeostasis as critical for resolving telomere entanglements in fission yeast through genetic screens and functional analysis.

This study identifies a physical interaction between Dmc1 and Mlh1-Mlh3 in yeast meiosis and shows that Dmc1 promotes crossover resolution by recruiting Mlh1-Mlh3.

This study identifies the role of Ranbp2's cyclophilin domain in regulating crystallin proteostasis and neuroprotection in the chorioretina through proteomic analysis of genetically modified mice.

The paper investigates the effects of PACS1 and PACS2 variants on protein localization in C. elegans, showing altered localization and functional conservation with human proteins.