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This study identifies dynamic histone lactylation at meiosis-specific sites in mouse spermatogenesis, linking it to gene expression and recombination.

The paper shows that organisms with fewer slightly-deleterious variants are more likely to survive stress, leading to purifying selection on populations.

The paper identifies mutations in Snn1 genes that affect susceptibility to Septoria nodorum blotch and develops markers to eliminate these genes for improved wheat resistance.

The paper identifies a naive piRNA surveillance system that broadly monitors the germline transcriptome for newly invading elements, showing it is abundance-coupled and independent of canonical piRNA pathways.

This study shows that depletion of DNA primases in C. elegans activates the endoplasmic reticulum unfolded protein response (UPR-ER), which is required to alleviate replication stress.

The paper demonstrates that IS110 insertion sequences use a structured RNA to direct sequence-specific DNA recombination, enabling modular genome editing.

The paper develops a multiplex PCR test using COI gene data to identify biting midge species and clades, achieving high sensitivity for Culicoides subgenus Avaritia.

The paper investigates tissue-specific gene expression responses to copper stress in Drosophila melanogaster using differential expression analysis and eQTL mapping across 96 inbred strains.

This paper develops a SNP panel for high-resolution genetic assessment of European bison, enabling accurate genotyping from non-invasive samples and supporting conservation efforts.

This study investigates the function of two ecdysteroid kinase-like genes in Drosophila melanogaster using genetic approaches, finding that they may not directly inactivate ecdysteroids but could have novel roles in development.

The paper analyzes CYP2D6 variation in a multi-ethnic Asian cohort, identifying population-specific star alleles and actionable variants with implications for pharmacogenomics.

This paper presents a general model for analyzing two-locus assortative mating, providing closed-form expressions for linkage and identity disequilibrium in human populations.

The paper identifies gene expression changes and regulatory mechanisms underlying developmental divergence in the annelid Streblospio benedicti using RNAseq across ontogeny.

This study uses nanopore sequencing to resolve genotype-phenotype discrepancies in the Kidd blood group system by detecting structural variants and novel alleles.

The paper introduces causality-enriched epigenetic clocks, DamAge and AdaptAge, to track detrimental and adaptive methylation changes linked to aging, showing their association with adverse outcomes and beneficial adaptations.

This paper introduces a transformer-based model to predict cell type-specific DNA methylation regulatory variants and improves fine mapping for brain disorders.

This paper introduces PSMC+, an extension of the PSMC algorithm that accounts for background selection in demographic inference, improving accuracy in effective population size estimation.

The paper uses haplotype sharing trees and HAPTK to show that intermediate-length C9orf72 repeat alleles share haplotypes with the hexanucleotide repeat expansion, suggesting they are potential premutation alleles.

The paper integrates GWAS with scATAC-seq and scRNA-seq data to identify disease-critical fetal and adult brain cell types for multiple traits.

The paper compares epigenetic and genetic spatial structures in Mediterranean mountain plants, finding that narrow endemics show lower epigenetic differentiation than widespread congeners.