Discover, rate, and discuss biology preprints.

This study evaluates the testing network of a cowpea breeding program by analyzing genotype-environment interactions and site similarities to optimize multi-environment yield trials.

This paper integrates genetic, synaptic, and developmental expression data to show how synaptic characteristics influence clinical phenotypes in neurodevelopmental disorders.

The paper identifies non-coding variants associated with clonal hematopoiesis and demonstrates their regulatory impact on gene expression and clonal expansion.

The paper maps NMD-coupled alternative splicing events in iPSC-derived brain cells and identifies therapeutic targets for neurodevelopmental disorders.

This paper uses CRISPR to edit pennycress, reducing glucosinolates and weediness to create a high-yield, low-carbon crop for agricultural and fuel use.

This study identifies 68 genes associated with drought tolerance in Arabidopsis thaliana seedlings using GWAS and validates their roles through reverse genetics.

The paper uses a MAGIC population to study genetic architecture of clinal traits in Mexican maize, finding one major QTL for tassel branching and multiple QTL for flowering time with complex environmental associations.

This study uses CRISPR/Cas9 to edit pericentromeric satellite DNA in Drosophila and shows that copy number affects sensitivity to a meiotic drive system.

This study reviews DNA-based seafood identification methods and finds a 24.8% mislabeling rate in Eastern South Pacific seafood, with many cases involving threatened shark species.

The paper shows that phenotype scale choice affects GxE signals in biobank data, with log scaling revealing meaningful effects and explaining a significant portion of PGSxSex interactions.

This study maps spatially resolved molecular states in congenital melanocytic nevi and associated tumors, revealing distinct melanocyte subpopulations and signaling networks linked to disease progression.

The paper demonstrates that OGG1 uses coordinated amino acids to efficiently detect 8-oxoG lesions in DNA.

This paper demonstrates a method using engineered piggyBac transposase and CRISPR/Cas9 to achieve targeted integration of large DNA fragments into the human genome with high specificity and efficiency.

This study identifies high-yielding and stable cassava genotypes using GGE biplot and Yield Selection Index techniques across five Nigerian locations.

The paper confirms a 1-bp deletion in the MLANA gene causes sex-linked dilution in European domestic geese, leading to autosexing traits.

The paper identifies molecular QTL enriched for structural variants in a cattle long-read sequencing cohort, showing SVs have a significant impact on gene expression and splicing.

This study identifies novel fusion transcripts in mantle cell lymphoma using long-read sequencing, revealing their potential as therapeutic targets and biomarkers.

This study identifies ARID5B mutations as a cause of a neurodevelopmental syndrome with neuroinflammation episodes and describes clinical and functional consequences.

This study uses ultra-deep sequencing to analyze intra-host SARS-CoV-2 diversity and co-infection-driven evolution in Chilean patients, finding increased genetic diversity and positive selection in the Spike gene during co-infections.

MateR computes a new usefulness criterion and diversity metric for genomic mating, improving accuracy in predicting family means and variances and tracking additive variation loss.