Discover, rate, and discuss biology preprints.

This study shows that unsaturated fatty acids are essential for germline proliferation, DNA replication, meiotic progression, and membrane integrity in C. elegans.

The paper shows that a foreign tandem repeat can induce heterochromatin formation in Drosophila, with temperature-dependent silencing and distinct biochemistry compared to canonical PEV.

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

The paper develops longitudinal models to identify non-additive genetic effects on developmental plasticity, finding 76 novel loci involved in regulatory interactions.

This study examines how sperm fractionation methods affect chromosome positioning, chromatin integrity, and DNA methylation/hydroxymethylation levels in human sperm.

This study identifies a mechanism by which Cdc5 and Cdc14 coordinate to resolve DNA catenanes through regulation of Topoisomerase II during mitosis.

The paper investigates CO rates in mice, showing SC length isn't the sole factor, and highlights sex-specific regulation of CO designation.

This study shows that COPS5 is essential for Sertoli cell function and male fertility in mice, as its loss causes infertility through disrupted cell polarity, blood-testis barrier integrity, and gap junction communication.

This paper maps genetic linkage in cowpea using SNP and morphological markers, identifying Mendelian and non-Mendelian inheritance patterns and creating a genetic map for breeding improvement.

The paper identifies adipocyte-related genes associated with atrial fibrillation progression and prognosis using RNA-seq data and immune infiltration analysis.

The paper inserts rare autism variants in C. elegans synaptic genes and assesses their functional impact on behavior, revealing complex effects including loss and gain of function.

This study evaluates annual ryegrass genotypes for forage yield and blast resistance across two environments, finding significant genotype-by-environment interactions and recommending specific genotypes for stability and disease resistance.

The paper identifies a Kv6.4 variant that selectively reduces function without affecting other Kv6 subunits, suggesting it as a therapeutic target for uterine pain.

This study estimates the false sign rate in transcriptome-wide association studies (TWAS) for plasma proteins and complex traits, finding high discordance between predicted and expected gene effects.

The paper shows that antisense transcription can create expression memory through promoter repression in mouse embryonic stem cells, with memory capacity increasing during differentiation.

The paper identifies human-specific deletions that affect gene expression by using CRISPRi screening in chimpanzee stem cells.

This paper introduces SSED, a metric using ESM-3 to quantify evolutionary divergence, showing cancer driver genes are structurally constrained and that oncogenic mutations follow similar principles, predicting immune response.

The paper investigates the developmental dynamics and crosstalk between WAGO-1 and WAGO-3 in C. elegans, showing distinct regulatory roles and complex interactions with 22G-RNAs and 26G-RNAs.

This study shows that H2BE is required for activity-dependent gene expression and homeostatic scaling in neurons.

MIRAGE improves rare variant association analysis by incorporating variant functional information, outperforming existing methods in simulations and autism exome-sequencing data.