Xin He

The RNA modification N6-methyladenosine restrains SIRPα to license myeloid efferocytosis in atherosclerosis

This study identifies the m6A-SIRP axis as a regulator of efferocytosis in atherosclerosis, showing myeloid m6A loss increases plaque instability.

An innate immune circuit involving the lectin pathway, complement and lung epithelial cells enforce barrier immunity to inhaled fungal disease

Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells

This study identifies NKG7 as a regulator that promotes anti-fungal Th1 cell development and converts Th17 cells into polyfunctional memory Th1 cells.

Beyond the mean: genetic control of gene expression fidelity and dispersion

This paper shows that gene expression dispersion, not just mean expression, is a genetically controlled regulatory feature reflecting fidelity across species and cell types.

Single-cell multiomic profiling of lung immune cells identifies novel asthma risk genes and cell-type specific functions

The paper uses single-cell multi-omics data to identify asthma risk genes and their cell-type specific functions in lung immune cells.

MIRAGE: a Bayesian rare variant association analysis method incorporating functional information of variants

MIRAGE improves rare variant association analysis by incorporating variant functional information, outperforming existing methods in simulations and autism exome-sequencing data.

Super-giga and tiny orchid genomes illuminate evolution of Orchidaceae

The paper presents chromosome-level genomes for two orchids, revealing insights into their evolutionary relationships and genome size variation.

Identifying the genetic basis and molecular mechanismsunderlying phenotypic correlation between complex humantraits using a gene-based approach

This paper develops a gene-based approach to identify genetic overlaps and shared molecular mechanisms between complex human traits, revealing novel associations and pathways.

Limited contribution of rare, noncoding variation to autism spectrum disorder from sequencing of 2,076 genomes in quartet families

This study examines the role of noncoding variation in autism spectrum disorder using whole genome sequencing of 2,076 genomes, finding no significant association after correction for multiple testing.